Sökning: "medicinsk biokemi"

Visar resultat 21 - 25 av 428 avhandlingar innehållade orden medicinsk biokemi.

  1. 21. Exploiting enzyme promiscuity for rational design

    Författare :Cecilia Branneby; Karl Hult; Alex Zaks; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Candida antarctica lipase B; alanine racemase; substrate specificity; reaction specificity; enzyme catalytic promiscuity; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Enzymes are today well recognized in various industrial applications, being an important component in detergents, and catalysts in the production of agrochemicals, foods, pharmaceuticals, and fine chemicals. Their large use is mainly due to their high selectivity and environmental advantage, compared to traditional catalysts. LÄS MER

  3. 22. Lipase-Catalyzed Syntheses of Telechelic Polyesters

    Författare :Magnus Eriksson; Karl Hult; Mats Martinelle; Sergio Riva; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Candida antarctica lipase B; lipase-catalysis; polymerization; telechelic; functional polyesters; ring-opening polymerization; polycondensation.; Biochemistry; Biokemi;

    Sammanfattning : Telechelic polyesters have successfully been synthesized with lipase-catalyzed polymerization. The produced telechelics had a high degree of di­functionalization, high purity (requiring little or no workup) and controlled degree of polymerization. The syntheses were performed in one-pot one-step reaction systems. LÄS MER

  4. 23. Lipase Specificity and Selectivity : Engineering, Kinetics and Applied Catalysis

    Författare :Mohamad Takwa; Karl Hult; Bernhard Hauer; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : The specificity and selectivity of the enzyme Candida antarctica lipase B (CALB) were studiedfor several substrates and applications.With help of molecular modeling, the active site of CALB was redesigned for the ring openingpolymerization of D,D‐lactide. LÄS MER

  5. 24. Early events in disease associated protein misfolding

    Författare :Sofie Nyström; Per Hammarström; Marcus Fändrich; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi;

    Sammanfattning : The scope of this thesis is to unravel some of the mysteries concerning events takingplace early in the amyloid cascade. In vitro studies of early misfolded states ofamyloidogenic proteins are important since the use of recombinant proteins allow us to monitor slight changes in environmental conditions as well as in amino acid composition and thereby illuminate the problem at near atomic resolution. LÄS MER

  7. 25. Molecular Aspects of Transthyretin Amyloid Disease

    Författare :Karin Sörgjerd; Per Hammarström; Joel Buxbaum; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid; apoptosis; BiP; chaperone; misfolding; oligomer; transthyretin; Biochemistry; Biokemi;

    Sammanfattning : This thesis was made to get a deeper understanding of how chaperones interact with unstable, aggregation prone, misfolded proteins involved in human disease. Over the last two decades, there has been much focus on misfolding diseases within the fields of biochemistry and molecular biotechnology research. LÄS MER