Sökning: "locally optimal designs"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden locally optimal designs.
1. Topics in optimal design of experiments
Sammanfattning : This thesis contributes to optimal design of experiments in situations where the optimal design depends on unknown parameters. Such situations often occur when the response variable does not have normal distribution, as is the case with many generalized linear models (GLM) and many models for binary response. LÄS MER
2. Optimal adaptive designs and adaptive randomization techniques for clinical trials
Sammanfattning : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. LÄS MER
3. Estimation and optimal designs for multi-response Emax models
Sammanfattning : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. LÄS MER
4. Locally D-optimal Designs for Bivariate Logistic Regression
Sammanfattning : .... LÄS MER
5. Optimal design for dose-finding studies
Sammanfattning : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. LÄS MER