Sökning: "locally optimal designs"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden locally optimal designs.

  1. 1. Topics in optimal design of experiments

    Författare :Sofia Normark; Hans Nyquist; Johan Lyhagen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; optimal design; factorial experiments; minimax designs; efficiency; locally optimal designs; generalized linear models; binary data; statistik; Statistics;

    Sammanfattning : This thesis contributes to optimal design of experiments in situations where the optimal design depends on unknown parameters. Such situations often occur when the response variable does not have normal distribution, as is the case with many generalized linear models (GLM) and many models for binary response. LÄS MER

  3. 2. Optimal adaptive designs and adaptive randomization techniques for clinical trials

    Författare :Yevgen Ryeznik; Warwick Tucker; Andrew Hooker; Franz König; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; optimal designs; optimal adaptive designs; randomization in clinical trials; restricted randomization; adaptive randomization; unequal cost; allocation ratio preserving randomization procedures; heterogeneous costs; multi-arm clinical trials; randomization-based inference; unequal allocation; Tillämpad matematik och statistik; Applied Mathematics and Statistics;

    Sammanfattning : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. LÄS MER

  4. 3. Estimation and optimal designs for multi-response Emax models

    Författare :Bergrún Tinna Magnúsdóttir; Hans Nyquist; Ziad Taib; Nancy Flournoy; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; multi-response Emax models; Clinical Utility Index CUI ; optimal designs; system estimation; dose-response studies.; Statistics; statistik;

    Sammanfattning : This thesis concerns optimal designs and estimation approaches for a class of nonlinear dose response models, namely multi-response Emax models. These models describe the relationship between the dose of a drug and two or more efficacy and/or safety variables. LÄS MER

  5. 4. Locally D-optimal Designs for Bivariate Logistic Regression

    Författare :Jari Appelgren; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Statistik; Statistics;

    Sammanfattning : .... LÄS MER

  7. 5. Optimal design for dose-finding studies

    Författare :Renata Eirini Tsirpitzi; Frank Miller; Kirsten Schorning; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; bivariate model; distortion; drug combination; Elfving set; Emax model; Fedorov algorithm; mixed effects models; optimal experimental design; Statistics; statistik;

    Sammanfattning : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. LÄS MER