Sökning: "drug combination"

Visar resultat 1 - 5 av 542 avhandlingar innehållade orden drug combination.

  1. 1. Studies of Retroviral Reverse Transcriptase and Flaviviral Protease Enzymes as Antiviral Drug Targets : Applications in Antiviral Drug Discovery & Therapy

    Författare :Muhammad Junaid; Jarl ES Wikberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virus; enzymes; HIV AIDS; retroviral reverse transcriptase; flaviviral protease; NRTIs; proteochemometrics; drug resistance; DEN; JEV; NS2B H -NS3pro; antiviral; drug targets; drug discovery; drug therapy.; Farmakologi; Pharmacology;

    Sammanfattning : Viruses are a major threat to humans due to their unique adaptability, evolvability and  capability to control their hosts as parasites and genetic elements. HIV/AIDS is the third largest cause of death by infectious diseases in the world, and drug resistance due to the viral mutations is still the leading cause of treatment failure. LÄS MER

  3. 2. Drug Analysis : Bioanalytical Method Development and Validation

    Författare :Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Nyckelord :Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. LÄS MER

  4. 3. Circumventing drug resistance : Studies exploring the expediency of a total cell kill chemoresistance assay

    Författare :Bertil Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; drug resistance; drug resistance assay; clinical correlations; cancer; human; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Cellular resistance to anti-cancer drugs is considered to be the major cause of treatment failure in clinical practice. The present studies have therefore focused on ways to circumvent resistance as evaluated by an in vitro chemoresistance assay. LÄS MER

  5. 4. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies

    Författare :Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Nyckelord :cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

    Sammanfattning : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. LÄS MER

  7. 5. Modeling of combination therapy to support drug discovery in oncology

    Författare :Tim Cardilin; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pharmacokinetics Pharmacodynamics; Oncology; Nonlinear Mixed-Effects Models; Model-Based Drug Development; Combination Therapy;

    Sammanfattning : Mathematical models based on ordinary differential equations, with impulses, are used to describe tumor growth after different treatment combinations, including chemicals as well as radiation. The models are calibrated, using a nonlinear mixed-effects framework, based on time series data of tumor volume from animal experiments. LÄS MER