Sökning: "leukotriene receptor antagonist"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden leukotriene receptor antagonist.

  1. 11. Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle

    Författare :Magnus Bäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors have been cloned, CysLT, and CysLT2. LÄS MER

  3. 12. The role of CysLT1R in animal models of colorectal cancer

    Författare :Sayeh Savari; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. LÄS MER

  4. 13. Regulation of experimentally induced airway obstruction

    Författare :Eva G. Lindström; Jan Lötvall; Linköpings universitet; []
    Nyckelord :airway obstruction; antigen; capsaicin; epithelium; inflammatory mediators; sensory neurons; tube preparation; tachykinins; formoterol; histamine; presynaptic inhibition; in vitro; guinea pig; MEDICINE; MEDICIN;

    Sammanfattning : Asthma is one of the commonest diseases in industrialized countries. The cause and mechanisms of !he disorder are still not fully unden;tood, al!hough it is known that inflammation in !he airways plays an important role. Inflammatory mediators, e.g. LÄS MER

  5. 14. Surgical trauma, inflammation and tissue injury

    Författare :Leif Törkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Activated partial thromboplastin time; blood flow; blood pressure; CD18; calcitonin gene-related peptide; dalteparin; glucocorticoids; heparin; intravital microscopy; leukotrienes; myeloperoxidase; neutrophils; stress; surgical flaps; rat;

    Sammanfattning : Surgical tissue trauma is a strong stimulus for local inflammation, including leukocyte recruitment. While such a response may be of importance for the defense against microorganisms, it is also clear that inflammation may contribute to further tissue injury. LÄS MER

  7. 15. An experimental study of mediators in allergic bronchoconstriction with focus on eicosanoids

    Författare :Ewa Selg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Leukotrienes; prostaglandins; histamine; guinea pig lung; ovalbumin; mast cell; cyclooxygenase; airway smooth muscle; COX inhibitors; NSAIDs;

    Sammanfattning : Mast cells have a central role in the inflammatory response in airways of both atopic and non-atopic asthmatics. The mast cell-derived mediators such as histamine, leukotriene C4 and prostaglandin D2, released upon activation of the cell, produce acute bronchoconstriction that is characteristic of the early asthmatic response (EAR), and contribute to the development of airway inflammation and hyperresponsiveness following the initial reaction. LÄS MER