Sökning: "NSAIDs"

Visar resultat 1 - 5 av 54 avhandlingar innehållade ordet NSAIDs.

  1. 1. Heterotopic Ossification : Clinical and Experimental Studies on Risk Factors, Etiology and Inhibition by Non-steroidal Anti-inflammatory Drugs

    Författare :Per-Erik Persson; Olle Nilsson; Per Aspenberg; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Heterotopic ossification; Hip prosthesis; NSAIDs; Prophylaxis; Prosthesis loosening; Reoperation; Animal model; Bone formation; Kirurgi; Surgery; Kirurgi;

    Sammanfattning : In this thesis, occurrence of heterotopic ossification (HO) following total hip arthroplasty (THA) was studied. Preventive effects and complications with non-steroidal anti-inflammatory drugs (NSAIDs) were analyzed. Experimental investigations on bone formation were employed to gain insight to the mechanism of NSAIDs action on bone.(I). LÄS MER

  2. 2. Angiotensin converting enzyme inhibition and aspirin in congestive heart failure

    Författare :Tord Juhlin; Kardiologiska klinikens forskargrupp; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clinical trial; ARBs; renal function; congestive heart failure; ischaemic heart disease; NSAIDs; ACE-inhibitors; aspirin; dose dependency; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : Angiotensin-converting enzyme (ACE) inhibitors act by decreasing production of angiotensin II and by potentiating the effects of bradykinin by inhibition of its breakdown. Bradykinin exerts part of its effects via vasodilating prostaglandins. Since the cyclooxygenase (COX)-inhibitors, e.g. LÄS MER

  3. 3. Computational studies of photodynamic drugs, phototoxic reactions and drug design

    Författare :Klefah Abrahem Klefah Musa; Leif Eriksson; Nino Russo; Örebro universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NSAIDs; fluoroquinolone; photodegradation; phototoxicity; drug design; DFT; TD-DFT; Biophysical chemistry; Biofysikalisk kemi; Kemi; Chemistry;

    Sammanfattning : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. LÄS MER

  4. 4. Oxidative stress and proteolysis in the lens. Effects of anti-inflammatory drugs

    Författare :Anne Kling-Petersen; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidation NSAIDs ASA dexamethasone apoptosis GSH GSSG proteasome lens epithelial cells mouse lens cataract;

    Sammanfattning : Oxidative stress has been implied in formation of age-related cataract. The objectives of this thesis were to study redox regulation of proteolysis and oxidative/antioxidative effects of anti-inflammatory substances in human lens epithelial cells (HLEC) and intact mouse lenses. LÄS MER

  5. 5. Drug use in the elderly : risk or protection? Findings from the Kungsholmen project

    Författare :Christel Cornelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Drug use; elderly; dementia; Alzheimer s disease; aspirin; NSAIDs; glucocorticoids; calcium channel blockers; apolipoprotein E; population-based study.;

    Sammanfattning : This thesis deals with different aspects of drug use in a population-based study with participants 75 years and older. The study was performed within the Kungsholmen Project in Stockholm, Sweden, using data from the baseline survey (1987-89), and the first (1991-93) and second (1994-96) followups In the first two papers we used cross-sectional data (n=1810) to describe tile drug Ilse pattern ill this population (I), and to examine the association between self-reported symptoms and drug use (II). LÄS MER