Sökning: "leukotriene B4"

Visar resultat 16 - 20 av 39 avhandlingar innehållade orden leukotriene B4.

  1. 16. Function of B2-adrenoceptors on alveolar macrophages

    Författare :Anita Zetterlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :A;

    Sammanfattning : B2-Agonists are very effective drugs for bronchodilatation, provide a rapid relief of symptoms in asthma, and are recommended as first line treatment, together with steroids. The relaxation of bronchial smooth muscles is a well-established effect of B-agonists, but their effects on inflammatory cells in the airways are less certain. LÄS MER

  3. 17. Biosynthesis and biological role of leukotrienes in human lymphocytes

    Författare :Yilmaz Mahshid; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4. Leukotriene B4 is a potent proinflammatory and chemotactic mediator. LÄS MER

  4. 18. Discovery of Novel Receptors for Lipid Mediators - a study leading to the identification of receptors involved in metabolism and the immune system

    Författare :Niclas Nilsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; Thiazolidinedione; SCFA; FFA; FFA2R; FFA1R; GPR43; GPR41; GPR40; BLT2; GPCR; Orphan; Receptor;

    Sammanfattning : Intercellular communication is of crucial importance in regulating physiology and G-protein coupled receptors (GPCRs) have evolved as an important mechanism in this process. Of the approximately 800 human GPCRs, about 160 are still considered to be “orphan” receptors for which an endogenous ligand remains to be identified. LÄS MER

  5. 19. Surgical trauma, inflammation and tissue injury

    Författare :Leif Törkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Activated partial thromboplastin time; blood flow; blood pressure; CD18; calcitonin gene-related peptide; dalteparin; glucocorticoids; heparin; intravital microscopy; leukotrienes; myeloperoxidase; neutrophils; stress; surgical flaps; rat;

    Sammanfattning : Surgical tissue trauma is a strong stimulus for local inflammation, including leukocyte recruitment. While such a response may be of importance for the defense against microorganisms, it is also clear that inflammation may contribute to further tissue injury. LÄS MER

  7. 20. Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment

    Författare :Karina Roxana Gheorghe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The past years have witnessed tremendous progress in the treatment of rheumatoid arthritis, a chronic debilitating autoimmune disease mainly characterized by joint inflammation with progressive tissue destruction and loss of function. This condition affects 0. LÄS MER