Sökning: "knot"

Visar resultat 16 - 20 av 60 avhandlingar innehållade ordet knot.

1. 16. Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides

   Författare :Anders Herrmann; Ulf Göransson; Lars Bohlin; Douglas Kinghorn; Uppsala universitet; []
   Nyckelord :Pharmacognosy; cyclotide; cytotoxic; anti-tumour; macrocyclic; cyclic cystine knot; Alpine violet; Sweet violet; Viola; Violaceae; chemical modifications; structure-activity studies; mass spectroscopy; cDNA clones; Farmakognosi;

   Sammanfattning : Cyclotides are a family of small and macrocyclic proteins that have been found in Violacaee and Rubiaceae plant species. These proteins contain a cystine knot: two disulfides bonds together with their connecting peptide backbone form an embedded ring which is penetrated by a third disulfide bond. LÄS MER

3. 17. Cyclotides evolve : Studies on their natural distribution, structural diversity, and activity

   Författare :Sungkyu Park; Göransson Ulf; Lars Bohlin; Mohamed Marahiel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cyclotide; cyclic cystine knot; evolution; peptide synthesis; chemical ligation; QSAR; Viola; Violaceae; phylogeny; Farmakognosi; Pharmacognosy;

   Sammanfattning : The cyclotides are a family of naturally occurring peptides characterized by cyclic cystine knot (CCK) structural motif, which comprises a cyclic head-to-tail backbone featuring six conserved cysteine residues that form three disulfide bonds. This unique structural motif makes cyclotides exceptionally resistant to chemical, thermal and enzymatic degradation. LÄS MER

4. 18. Cytotoxic Cyclotides : Structure, Activity, and Mode of Action

   Författare :Erika Svangård; Per Claeson; Lars Bohlin; Ulf Göransson; John H. Cardellina II; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; cyclotide; cytotoxic; cancer; cyclic cystine knot; Viola; Violaceae; liposome; hollow fibre; homology modelling; mass spectrometry; amphipathic; structure–activity; tumour; membrane disruption; necrosis; Farmakognosi; Pharmacognosy; Farmakognosi;

   Sammanfattning : Cyclotides are small cyclic plant proteins, and this thesis addresses their cytotoxic structure-activity properties and their mode of action on human cancer cell lines. Cyclotides were isolated from Viola odorata and Viola tricolor; three novel cyclotide sequences and two known sequences, but of new origin, were identified using mass spectrometry, amino acid analysis, and Edman degradation. LÄS MER

5. 19. CUnT-SPLICING THOUGHT-FORMS : Promiscuous Play with Quantum Physics and Spirituality

   Författare :Lea Porsager; Konsthögskolan i Malmö; []
   Nyckelord :HUMANIORA; HUMANITIES; Artmaking; Excited states; Rope-work; Thought-Forms; Agential realism; Quantum mysticism; Tantra;

   Sammanfattning : CUnT-SPLICING THOUGHT-FORMS — Promiscuous Play with Quantum Physics and Spirituality could perhaps best be described as an invocation of excited states. In more ways than one, this dissertation indulges in a weird threesome between quantum thinking, tantric practices, and feminist theory, with artistic practice at its core. LÄS MER

7. 20. Chekanov-Eliashberg dg-algebras and partially wrapped Floer cohomology

   Författare :Johan Asplund; Tobias Ekholm; Baptiste Chantraine; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Symplectic geometry; Contact geometry; Chekanov-Eliashberg dg-algebra; partially wrapped Floer cohomology; Lagrangian submanifold; Legendrian submanifold; singular Legendrians; based loop space; Mathematics; Matematik;

   Sammanfattning : This thesis consists of an introduction and two research papers in the fields of symplectic and contact geometry. The focus of the thesis is on Floer theory and symplectic field theory. LÄS MER