Sökning: "anti-tumour"
Visar resultat 1 - 5 av 36 avhandlingar innehållade ordet anti-tumour.
1. Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides
Sammanfattning : Cyclotides are a family of small and macrocyclic proteins that have been found in Violacaee and Rubiaceae plant species. These proteins contain a cystine knot: two disulfides bonds together with their connecting peptide backbone form an embedded ring which is penetrated by a third disulfide bond. LÄS MER
2. Specific anti-tumour effects of 6-diazo-5-oxo-L-norleucine (DON) on carcinoid tumour cells
Sammanfattning : Glutamine is essential for cell growth. 6-diazo-5-oxo-L-norleucine (DON) is a rather old anti-tumour drug developed as a glutamine antagonist. Previous clinical trials with DON, not including carcinoid tumours, did not prove convincing. Hence the drug was not further used. LÄS MER
3. Anti-tumour effect in solid tumours, tolerance and immune reconstition after allogeneic haematopoietic stem cell transplantation
Sammanfattning : Both in haematological malignancies and in disseminated solid tumours, re-occurrence of the underlying disease is the main complication. Allogeneic haematopoietic stem cell transplantation (HSCT) increases the chance of cure compared to only chemotherapy in haematological malignancies, but adds the risk of immunological complications such as graft-versus-host disease (GVHD) and severe infections. LÄS MER
4. DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity
Sammanfattning : The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes two processes, V(D)J recombination and lg switch recombination, during which DSBs are naturally occurring events. LÄS MER
5. MESENCHYMAL STEM- AND STROMAL CELLS IN BONE MARROW AND OSTEOSARCOMA
Sammanfattning : Primary mesenchymal stem cells (MSC) play a central role in bone marrow (BM) and during haematopoiesis. Yet, the exact phenotype and spatial distribution of primary MSC in the human BM are unknown. Their cultured progeny are promising candidates for clinical applications. LÄS MER