Sökning: "macrocyclic"

Visar resultat 1 - 5 av 46 avhandlingar innehållade ordet macrocyclic.

  1. 1. Macrocyclic polypeptides from plants

    Författare :Ulf Göransson; David Craik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Pharmacognosy; Farmakognosi;

    Sammanfattning : The aim of this work was to explore the structural and functional diversity of polypeptides that are found in plants. Expanding knowledge of simililarities between plant use of these compound and animal use promises exceptional opportunities for finding, from plant research, new structures with biomedical and biotechnological potential. LÄS MER

  3. 2. A Microcalorimetric Study of Macrocyclic Complexes in Aqueous Solution

    Författare :Magnus Stödeman; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Aqueous Solution; Calixarene; Cyclodextrin; Vaporization; Macrocyclic compounds; Microcalorimetry; Kemi;

    Sammanfattning : The present work involves a microcalorimetric characterization of the interactions among macrocyclic compounds and aliphatic molecules in aqueous solution. The macrocyclic compounds used in the study are a-,b- and g-cyclodextrin and 25,26,27,28-tetrahydroxycalix[4]arene-5,11,17,23- tetrasulphonate. LÄS MER

  4. 3. Synthesis and Studies of NADH Models: Stereoselective Reductions and Host-Guest Properties

    Författare :Ulrik Gran; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; synthesis; NADH model; host-guest complex; stereoselective reductions; macrocyclic; reducing agent;

    Sammanfattning : The aim of the project has been to synthesise macrocyclic NADH models and to study them as reducing agents and hosts. Three types of macrocyclic NADH models have been synthesised. They consist of the same subunits; a chiral unit, a nicotinamide unit and an aromatic spacer. LÄS MER

  5. 4. Structure and Activity of Circular Plant Proteins : Cytotoxic Effects of Viola Cyclotides

    Författare :Anders Herrmann; Ulf Göransson; Lars Bohlin; Douglas Kinghorn; Uppsala universitet; []
    Nyckelord :Pharmacognosy; cyclotide; cytotoxic; anti-tumour; macrocyclic; cyclic cystine knot; Alpine violet; Sweet violet; Viola; Violaceae; chemical modifications; structure-activity studies; mass spectroscopy; cDNA clones; Farmakognosi;

    Sammanfattning : Cyclotides are a family of small and macrocyclic proteins that have been found in Violacaee and Rubiaceae plant species. These proteins contain a cystine knot: two disulfides bonds together with their connecting peptide backbone form an embedded ring which is penetrated by a third disulfide bond. LÄS MER

  7. 5. Discovery of Novel Macrocyclic Ligands for Difficult Targets : Applications to Natural Product Derived Keap1 Inhibitors

    Författare :Fabio Begnini; Jan Kihlberg; Anders Bach; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; Keap1-Nrf2; Protein-protein interactions; Natural products;

    Sammanfattning : The development of small-molecule ligands for biological targets that possess large, featureless or highly polar binding sites is a challenging task. This thesis is focused on a novel lead generation strategy to identify macrocyclic ligands for difficult-to-drug targets, as well as on the relationship between cell permeability and the conformations of macrocycles. LÄS MER