Sökning: "structure-activity studies"
Visar resultat 1 - 5 av 80 avhandlingar innehållade orden structure-activity studies.
1. Enzymatic characterization of inhibitors of HIV-1 proteinase : structure-activity and resistance studies
Sammanfattning : .... LÄS MER
2. Lysophosphatidic acid : Physiological effects and structure-activity relationships
Sammanfattning : Lipids havepreviously been considered primarily as building blocks of the cell membrane, but are now also recognized as important cell signaling molecules. Lysophosphatidic acid (LPA) is a glycerophospholipid consisting of a phosphate head group, a linker region, and a lipophilic tail. LÄS MER
3. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies
Sammanfattning : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. LÄS MER
4. Structure-activity studies of novel colchicine analogs
Sammanfattning : Colchicine, a well-known alkaloid isolated from Colchicum autumnale, interferes with microtubule growth and, therefore affects mitosis and other microtubule dependent functions. We have been interested in the structural requirements of colchicine for tubulin recognition. LÄS MER
5. Bioactive Compounds in the Chemical Defence of Marine Sponges : Structure-Activity Relationships and Pharmacological Targets
Sammanfattning : Marine invertebrates, in particular sponges, represent a source of a wide range of secondary metabolites, many of which have been attributed various defensive capabilities against environmental stress factors. In this thesis sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets. LÄS MER