Avancerad sökning

Visar resultat 16 - 20 av 443 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Molecular Markers and Hypoxia in Renal Cell Carcinoma

    Författare :Roger de Alwis; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney cancer; CTC; RCC; Hypoxia; SEMA5B; Prognostic markers;

    Sammanfattning : Renal cell carcinomas (RCCs) are a group of tumours that arise from the nephron within the kidney. They are characterised by an indolent growth pattern and do not display overt clinical symptoms in patients with early to locally advanced tumours. LÄS MER

  3. 17. Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells

    Författare :Tobias Löfstedt; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Biomedicinska vetenskaper; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; Biomedical sciences; MXI1; ID2; differentiation; HIF; hypoxia; transcription; cancer; neuroblastoma; Cytologi; onkologi;

    Sammanfattning : Cancer is a major cause of human morbidity and mortality, and the risk of developing cancer is about one in three life times. Neuroblastoma is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. LÄS MER

  4. 18. Hypoxia and Stem Cells in Normal and Tumor Development

    Författare :Camilla Niklasson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; hypoxia; preclinical cancer models; ALDH; HIF-2α; PT2385;

    Sammanfattning : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. LÄS MER

  5. 19. The role of hypoxia for the development of diabetic nephropathy : Temporal relationship and involvement of endothelin receptor signaling

    Författare :Stephanie Franzén; Fredrik Palm; Pamela K. Carmines; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephropathy; diabetes; hypoxia; EPR;

    Sammanfattning : Diabetic nephropathy is one of the most common causes of end stage renal disease and develops in approximately one third of all diabetes patients. Disease progression is characterized by deteriorating glomerular filtration rate and escalating urinary albumin/protein excretion; both are used as clinical markers for disease progression. LÄS MER

  7. 20. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

    Författare :Alexander Pietras; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

    Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER