Sökning: "ALDH"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet ALDH.

  1. 1. Hypoxia and Stem Cells in Normal and Tumor Development

    Författare :Camilla Niklasson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; hypoxia; preclinical cancer models; ALDH; HIF-2α; PT2385;

    Sammanfattning : Neuroblastoma is a childhood malignancy of the sympathetic nervous system and accounts for 15% of all cancer-related deaths in children. To understand the biology behind neuroblastoma, clarify timing of cellular events and expression profiles of proteins preceding neuroblastoma initiation, we need more relevant preclinical models. LÄS MER

  3. 2. Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood

    Författare :Sofia Frändberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cord blood; Cord blood bank; Cord clamping; Hematopoietic stem cell transplantation; Hematopoietic stem and progenitor cells; CD34; Side Population; Aldehyde dehydrogenase; Apoptosis; CDCP1;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. LÄS MER

  4. 3. The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)

    Författare :Kishan Bellamkonda; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Colorectal cancer (CRC) is one of the major causes of cancer globally. Recent studies proposed a role for cancer initiating cells (CICs), a small subset of replication-competent cells, in colon carcinogenesis. LÄS MER

  5. 4. Medium chain dehydrogenases/reductases : alcohol dehydrogenases of novel types

    Författare :Annika Norin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alcohol dehydrogenase; Nicotinoproteins; Structural interpretations; Functional properties; Molecular evolution.;

    Sammanfattning : The medium chain dehydrogenase/reductase (MDR) superfamily is separated into at least eight families, of which the dimeric alcohol dehydrogenase (ADH) is one. Including species variants, close to 1000 MDR forms have been characterized. LÄS MER

  7. 5. Regulation of normal and cancer cells as a base for cell cycle-targeted therapy

    Författare :Regina Miftakhova; Malmö Experimentell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell cycle regulation; cyclin A1; stem cells; stem cell niche; epigenetics; cancer;

    Sammanfattning : The majority of current treatments used for treatment of prostate cancer (PCa) and leukemia are often limited to a narrow subsets of treated patients. As such, there still remains a significant scope for gaining deeper understanding of molecular mechanisms underlying cancer metastasis for improvement of targeted treatment. LÄS MER