Sökning: "growth hormone receptor"

Visar resultat 26 - 30 av 155 avhandlingar innehållade orden growth hormone receptor.

  1. 26. Growth factors in spermatogenesis

    Författare :Aida Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Testis; seminiferous tubules; proliferation; growth factors; sex steroids;

    Sammanfattning : The aim of this study was to increase the knowledge of die effects of locally produced growth factors and hormones on germ cell proliferation in rat testis in vitro. Since impaired sperm production and function accounts for half the cases of infertility, it is important to understand the physiological actions in germ cell development. LÄS MER

  3. 27. Hormone replacement therapy in rheumatoid arthritis

    Författare :Helena Forsblad d'Elia; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; randomised controlled trials; hormone replacement therapy; estrogen; osteoporosis; bone mineral density; bone remodelling; cartilage remodelling; cytokines; insulin-like growth factor 1;

    Sammanfattning : Rheumatoid arthritis (RA) is 2-3 times more frequent in women as compared to men. The peak incidence in women coincides with the years around the menopause and the course of RA is also influenced by events associated with hormonal alterations. LÄS MER

  4. 28. Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism

    Författare :Mikael Bjursell; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Energy homeostasis ? the balance of energy intake, expenditure, and storage ? is controlled by autonomic regulation originating in the hypothalamus and the brain stem, which receive input from the periphery. Upon receiving signals from the periphery, centres in the central nervous system (CNS) react through endocrine or neuronal responses to maintain a steady balance. LÄS MER

  5. 29. GH Secretion in children. Methodological aspects of determining immunoreactive and bioactive isoforms

    Författare :Chatarina Löfqvist; Göteborgs universitet; []
    Nyckelord :Growth hormone; immunoassay; cross-reactivity; standard; antibody; insulin-like growth factor 1; reference values;

    Sammanfattning : A child's hormone-dependent growth is dependent on multiple factors, although linear growth is closely associated with levels of growth hormone (GH) secretion. As GH in serum exists in several isoforms, some of which may not be identified by immunoassay, possible alterations in the secretion of these different isoforms in childhood may influence growth and/or metabolism. LÄS MER

  7. 30. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

    Författare :Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
    Nyckelord :Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

    Sammanfattning : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. LÄS MER