Sökning: "cartilage remodelling"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden cartilage remodelling.

  1. 1. Extracellular Matrix Remodelling-Proteoglycan and collagen turnover in arthritis

    Författare :Anette Bjärdahlen; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; collagen; cartilage; myofibroblasts; pannus; proteoglycan; Skeleton; muscle system; rheumatology locomotion; reumatologi; Skelett; muskelsystem;

    Sammanfattning : Rheumatoid arthritis is a chronic, inflammatory and systemic disease characterised by joint destruction and pannus formation. To enlarge the understanding how pannus and granulation tissue are formed two animal models were used; one using cartilage wrapped in cotton and implanted into a rat air pouch (AP) and one where mBSA induced arthritis (AIA) was performed. LÄS MER

  3. 2. Hormone replacement therapy in rheumatoid arthritis

    Författare :Helena Forsblad d'Elia; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; randomised controlled trials; hormone replacement therapy; estrogen; osteoporosis; bone mineral density; bone remodelling; cartilage remodelling; cytokines; insulin-like growth factor 1;

    Sammanfattning : Rheumatoid arthritis (RA) is 2-3 times more frequent in women as compared to men. The peak incidence in women coincides with the years around the menopause and the course of RA is also influenced by events associated with hormonal alterations. LÄS MER

  4. 3. Cartilage Oligomeric Matrix Protein (COMP). Functions in collagen binding and assembly

    Författare :Krisztina Rosenberg; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical biology; Klinisk biologi;

    Sammanfattning : Connective tissues contain a prominent extracellular matrix that provides mechanical and physical properties. This extracellular matrix contains as a major constituent a network of collagen fibres. These are composed of collagen fibrils, which in turn are assembled from many collagen molecules aligned parallel to each other. Several proteins, e. LÄS MER

  5. 4. Chondrocyte and extracellular matrix alterations in equine cartilage during development and inflammation

    Författare :Maria Löfgren; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Osteoarthritis (OA) is a disease involving inflammation and subsequent degeneration of joint tissues. The disease progresses with time-dependent stages of degeneration, loss and remodelling of the extracellular matrix (ECM) of articular cartilage, and phenotypical changes in the chondrocytes. LÄS MER

  7. 5. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

    Författare :Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. LÄS MER