Sökning: "glucagon secretion"
Visar resultat 11 - 15 av 78 avhandlingar innehållade orden glucagon secretion.
11. Characterization of Impaired Glucose Tolerance - Insulin Sensitivity, Islet Function and Metabolic Risk Factors
Sammanfattning : This thesis presents a three-year prospective study on metabolic characteristics of impaired glucose tolerance (IGT) and the regulation of insulin sensitivity versus islet function in relation to changes in glucose tolerance. 108 non-diabetic women aged 57-58 years were randomly selected from a population of women born in 1935 with a high prevalence of IGT. LÄS MER
12. The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
Sammanfattning : Islet dysfunction is central to the development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. LÄS MER
13. Control of metabolism and hormone secretion from pancreatic alpha and beta cells
Sammanfattning : Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. LÄS MER
14. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
Sammanfattning : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). LÄS MER
15. The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion
Sammanfattning : Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. LÄS MER