Sökning: "Alpha-cells"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet Alpha-cells.

1. 1. Regulation of glucagon secretion from pancreatic alpha cells

   Författare :Yang De Marinis; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epac2; glucagon secretion; pancreatic alpha cells; K- ATP channel; N-type Ca2 channel; L-type Ca2 channel; GLP-1; cAMP; PKA; Adrenaline; PKC;

   Sammanfattning : Glucagon secreted by pancreatic α-cells plays an important role in the regulation of blood glucose. In this thesis, different techniques such as electrophysiology, immunohistochemistry and hormone secretion assay were combined to explore the mechanisms by which glucagon secretion is regulated. LÄS MER

3. 2. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

   Författare :Sofia A Andersson; Diabetes - öcellsexocytos; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

   Sammanfattning : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). LÄS MER

4. 3. Regulation of exocytosis by Ca2+ and cAMP - A study on pancreatic beta- and alpha-cells

   Författare :Xiaosong Ma; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endocrinology; secreting systems; type-2 diabetes; SUR1; Ca2 -channel; glucagon; exocytosis; insulin; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Type-2 diabetes is characterized by impaired insulin secretion associated with excess glucagon release. Exocytosis of insulin- or glucagon-containing granules is initiated by Ca2+-influx through voltage-dependent Ca2+-channels and is modulated by the second messengers such as cAMP. LÄS MER

5. 4. Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas

   Författare :Over Cabrera; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Human islet transplantation is emerging as an alternative to pancreas transplantation or insulin therapy in the treatment of type I diabetes. It has been possible to achieve euglycemia by transplanting isolated human islets in patients who suffer from the long term side effects of diabetes and insulin therapy. LÄS MER

7. 5. Expression of the glucose-6-phosphatase system in endocrine cells

   Författare :Bee-Hoon Goh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Glue os e- 6 -phphspatas e; G6PC; G6PT1; G6PC2; G6PC3; pancreatic islets; InR1G9 cells; GLUTag cells; glucagon producing a-cells; GLP-1 producing L-cells.;

   Sammanfattning : Glucose-6-phosphatase (G6pase) is a multi-component enzyme system, which regulates the catalysis of gluco se-6 -phosphate (G6P) to glucose and inorganic phosphate. This reaction constitutes the final steps of both gluconeogenesis and glycogenolysis, processes that are critical in the maintenance of glucose homeostasis. LÄS MER