Sökning: "genome-wide"

Visar resultat 21 - 25 av 523 avhandlingar innehållade ordet genome-wide.

  1. 21. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation

    Författare :Marie-Line Faucillion; Jan Larsson; Jean-Yves Roignant; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; dosage compensation; buffering; RNA stability; RNA decay; RNA half-life; RNA-seq; genome-wide; sex chromosomes; evolution; roX1; roX2; POF; MSL; molekylärbiologi; Molecular Biology;

    Sammanfattning : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). LÄS MER

  3. 22. Structure, prediction, evolution and genome wide studies of membrane proteins

    Författare :Erik Granseth; Arne Elofsson; Gunnar von Heijne; Mark Sansom; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Theoretical chemistry; Teoretisk kemi; biokemi; Biochemistry;

    Sammanfattning : α-helical membrane proteins constitute 20-30% of all proteins in a cell and are involved in many essential cellular functions. The structure is only known for a few hundred of them, which makes structural models important. LÄS MER

  4. 23. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Författare :Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER

  5. 24. Membrane protein topology : prediction, experimental mapping and genome-wide analysis

    Författare :Johan Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Membrane proteins constitute a large and important class of proteins. They are responsible for many crucial processes in living cells, and about 25% of all proteins encoded by a typical genome are predicted to be membrane proteins. Despite their importance, very few structures have been determined at atomic resolution. LÄS MER

  7. 25. From Single Gene to Whole Genome Studies of Human Transcription Regulation

    Författare :Alvaro Rada-Iglesias; Claes Wadelius; Henk Stunnenberg; Uppsala universitet; []
    Nyckelord :Genetics; transcription; ChIP-chip; genome-wide; transcription factors; in vivo; Genetik;

    Sammanfattning : Transcriptional regulation largely determines which proteins and the protein levels that are found in a cell, and this is crucial in development, differentiation and responses to environmental stimuli. The major effectors of transcriptional regulation are a group of proteins known as transcription factors, which importance is supported by their frequent involvement in mendelian and complex diseases. LÄS MER