Sökning: "genome-wide"

Visar resultat 16 - 20 av 523 avhandlingar innehållade ordet genome-wide.

  1. 16. Novel statistical methods for genome-wide association summary statistics

    Författare :Zheng Ning; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of the human genome project and developments of high-throughput technologies. LÄS MER

  3. 17. Population level genome-wide association studies in dairy cattle

    Författare :Xiaowei Mao; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In recent years, genome-wide association studies (GWAS) has become a dominant tool for detecting genetic architectures for complex traits. Thousands of associated genetic variants have been reported. However, the resolution of these studies was limited by the available marker density for the quantitative trait loci (QTL) region. LÄS MER

  4. 18. Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe

    Författare :Marianna Wirén; Karl Ekwall; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around histone proteins. LÄS MER

  5. 19. Candidate gene analyses and genome-wide screens in multiple sclerosis

    Författare :Vilmantas Giedraitis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Specific disease causing mutations have been identified for many disorders. Most of these disorders are of Mendelian origin and there have been very few successful attempts in the genetic dissection of complex traits. LÄS MER

  7. 20. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells

    Författare :Mehdi Motallebipour; Claes Wadelius; Gunnar Westin; Dirk Schübeler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transcription; ChIP-chip; ChIP-seq; genome-wide; transcription factors; microsatellite; epigenetic; Medical genetics; Medicinsk genetik;

    Sammanfattning : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. LÄS MER