Sökning: "roX1"

Hittade 4 avhandlingar innehållade ordet roX1.

  1. 1. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation

    Författare :Marie-Line Faucillion; Jan Larsson; Jean-Yves Roignant; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; dosage compensation; buffering; RNA stability; RNA decay; RNA half-life; RNA-seq; genome-wide; sex chromosomes; evolution; roX1; roX2; POF; MSL; molekylärbiologi; Molecular Biology;

    Sammanfattning : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). LÄS MER

  3. 2. Chromosome-wide gene regulatory mechanisms in Drosophila melanogaster

    Författare :Anna-Mia Johansson; Jan Larsson; Kristen M. Johansen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chromatin structure; Drosophila; POF; disage compensation; gene expression; MSL; heterochromatin; Genetics; Genetik; genetik; Genetics;

    Sammanfattning : In Drosophila there are two different chromosome-wide targeting systems, the dosage compensation system that equalizes the transcriptional output from X-linked genes between males and females, and the regulation of the 4th chromosome mediated by the POF protein.   The best studied of these two mechanisms is the dosage compensation system. LÄS MER

  4. 3. Systems Biology of Recombinant Protein Production by Fungi

    Författare :Lifang Liu; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Systems biology has emerged as a highly potent tool for studying biological processes over the last decades. However, its application to complex metabolic processes such as protein secretion is still at the infant stage. LÄS MER

  5. 4. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster

    Författare :Lina Lundberg; Jan Larsson; Brian Oliver; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genome-wide gene regulation; aneuploidy; buffering; HP1a; POF; SETDB1; Su var 3-9; MSL; roX; genetik; Genetics;

    Sammanfattning : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. LÄS MER