Sökning: "genetic screen"

Visar resultat 16 - 20 av 123 avhandlingar innehållade orden genetic screen.

  1. 16. Genetic Analyses of Tumor Progression in Colorectal Cancer

    Författare :Kristina Lagerstedt; Göteborgs universitet; []
    Nyckelord :colorectal cancer; tumor progression; microarray; DNA aberration; gene expression; microRNA; structural variation;

    Sammanfattning : Colorectal tumors are responsible for more than 600 000 deaths per year worldwide and thereby constitute the second most common cause of cancer related mortality. Early detection is related to improved prognosis and identification of genetic biomarkers would meliorate available diagnostic tools. LÄS MER

  3. 17. Genetic and molecular background of pheochromocytoma and paraganglioma

    Författare :Adam Stenman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pheochromocytomas (PCC) and abdominal paragangliomas (PGL), collectively denoted PPGL, are neuroendocrine tumors (NET) with a highly diverse genetic and molecular etiology, arisen in the adrenal medulla and abdominal paraganglia respectively. The tumors often cause cardiovascular symptoms due to the high production of catecholamines, and malignancy occurs in 10% of the PCCs and 30% of the PGLs. LÄS MER

  4. 18. Genetic mapping of retinal degenerations in Northern Sweden

    Författare :Linda Köhn; Irina Golovleva; Alison Hardcastle; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bothnia dystrophy; cone dustrophy; linkage analysis; mutation; PITPNM3; PRPF31; retinitis pigmentosa; RLBP1; Medical genetics; Medicinsk genetik; genetik; Genetics;

    Sammanfattning : Inherited retinal degenerations are a group of disorders characterised by great genetic heterogeneity. Clinically, they can be divided into two large groups of diseases, those associated with night blindness, e.g. retinitis pigmentosa (RP), and those with macular malfunction, e. LÄS MER

  5. 19. Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution

    Författare :Karin Wilbe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; genetic evolution; recombination; drug resistance; intrahost evolution;

    Sammanfattning : A striking characteristic of HIV is the enormous capacity of genetic variation. Frequent mutations, deletions, insertions and recombination events create a population of genetically related but non-identical viruses that is under constant change and ready to adapt to environmental changes. LÄS MER

  7. 20. Ischemic Stroke Outcomes - Analyses of Protein and Genetic Biomarkers

    Författare :Annie Pedersen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Stroke; Prognosis; Biomarkers; Genetics; Genome-Wide Association Study;

    Sammanfattning : The overall aim of this thesis was to identify novel biomarkers for ischemic stroke outcomes. The specific aims were to test the hypotheses that circulating concentrations of hemostatic biomarkers predict the long-term post-stroke risk of recurrent vascular events/death (paper I) and/or cognitive impairment (paper II) and that circulating concentrations of a marker of neuronal damage (neurofilament light chain, NfL) predict post-stroke functional and neurological outcomes (paper III) as well as to identify genetic variants associated with post-stroke functional outcome through a genome wide association study (GWAS) approach (paper IV). LÄS MER