Sökning: "genetic screen"

Visar resultat 21 - 25 av 123 avhandlingar innehållade orden genetic screen.

  1. 21. From genetic associations to biological implications in multiple sclerosis

    Författare :Wangko Lundström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Every year, 600 people in Sweden develop MS, making it the second most common cause of disability (after accidents) in young adults. The pathophysiology is characterized by inflammation of the central nervous system and impaired neuronal signaling. LÄS MER

  3. 22. A genetic study on familial breast cancer predisposing genes

    Författare :Liping Luo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer is the most common malignant disease among women in the western world and 10% of all breast cancer is assumed to constitute hereditary cases. Two major genes, BRCA1 and BRCA2, can only explain a fraction of familial breast cancer. The ATM carriers have high risk of developing breast cancer. LÄS MER

  4. 23. The clinical use of genetic analyses in colorectal cancer

    Författare :Susanne Tumlin Ekelund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Colorectal cancer (CRC) is a common global disease, with a mortality rate of almost 50%. Prognosis is mainly based on the TNM classification. Surgical interventions have the potential of being curative in patients with stage I-III CRC. Adjuvant treatment with chemotherapy enhances the survival rate, especially in stage III cancer. LÄS MER

  5. 24. Application of next generation sequencing in genetic and genomic studies

    Författare :Jingwen Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genetic variants that spread along the human genome play vital roles in determining our traits, affecting development and potentially causing disorders. Most common disorders have complex underlying mechanisms involving genetic or environmental factors and the interaction between them. LÄS MER

  7. 25. Molecular Genetic and DNA Methylation Profiling of Chronic Lymphocytic Leukaemia : A Focus on Divergent Prognostic Subgroups and Subsets

    Författare :Nicola Cahill; Richard Rosenquist; Larry Mansouri; Fergus Ryan; Denis Alexander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; Chronic lymphocytic leukemia; SNP; array; IGHV3-21; IGHV4-34; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Genetics; Genetik; Medical Genetics; Medicinsk genetik; Molecular Biology; Molekylärbiologi; Molekylär genetik; Molecular Genetics; Oncology; Onkologi;

    Sammanfattning : Advancements in prognostication have improved the subdivision of chronic lymphocytic leukaemia (CLL) into diverse prognostic subgroups. In CLL, IGHV unmutated and IGHV3-21 genes are associated with a poor-prognosis, conversely, IGHV mutated genes with a favourable outcome. LÄS MER