Sökning: "Genome-Wide Association Study"

Visar resultat 1 - 5 av 161 avhandlingar innehållade orden Genome-Wide Association Study.

1. 1. Genetic Analyses of Multiple Sclerosis and Systemic Lupus Erythematosus : From Single Markers to Genome-Wide Data

   Författare :Johanna K Sandling; Ann-Christine Syvänen; Lovisa Lovmar; Joseph Terwilliger; Javier Martín Ibáñez; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; Multiple Sclerosis; Association study; Type I interferon system; Single nucleotide polymorphism; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Molekylär medicin; Molecular Medicine;

   Sammanfattning : In autoimmune diseases an individual’s immune system becomes targeted at the body’s own healthy cells. The aim of this thesis was to identify genetic risk factors for the two autoimmune diseases multiple sclerosis (MS) and systemic lupus erythematosus (SLE). LÄS MER

3. 2. Genomic selection and genome-wide association studies to dissect quantitative traits in forest trees

   Författare :Biyue Tan; Pär K. Ingvarsson; Björn Sundberg; Harry X. Wu; Dario Grattapaglia; Xiao-Ru Wang; Leopoldo Sanchez; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Genomic prediction; genome-wide association study; additive effects; dominance effects; epistasis effects; realized relationship matrix; Eucalyptus grandis; Eucalyptus urophylla;

   Sammanfattning : The convergence of quantitative genetics of complex traits with genomic technologies is quickly becoming an innovative approach to explore fundamental genetic questions and also have practical consequences for implementations in tree breeding. In this thesis, I used genomic selection and genome-wide association studies (GWAS) to dissect the genetic basis of quantitative traits, i. LÄS MER

4. 3. Signals and Noise in Complex Biological Systems

   Författare :Johan Rung; Erkki Brändas; Måns Ehrenberg; Uppsala universitet; []
   Nyckelord :Engineering physics; complex systems; computational biology; gene networks; genome-wide; stochastic resonance; microarray; diabetes; association study; transcription regulation; gene expression; Teknisk fysik;

   Sammanfattning : In every living cell, millions of different types of molecules constantly interact and react chemically in a complex system that can adapt to fluctuating environments and extreme conditions, living to survive and reproduce itself. The information required to produce these components is stored in the genome, which is copied in each cell division and transferred and mixed with another genome from parent to child. LÄS MER

5. 4. Recurrent Aphthous Stomatitis - A study, with emphasis on host genetics, oral microbiota composition, and immunoregulatory networks

   Författare :Maria Bankvall; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aphthous stomatitis; Oral mucosa; Oral medicine; Genome-wide association study; Genetic linkage; Association; Genetic polymorphism; Microbiota; Restriction fragment length polymorphism; Antigen-presenting cell; T-lymphocyte; Lymph node; Flow cytometry;

   Sammanfattning : Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions. The aetiology is unknown and currently there is no consensus regarding suitable treatment regimens. LÄS MER

7. 5. Novel statistical methods for genome-wide association summary statistics

   Författare :Zheng Ning; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of the human genome project and developments of high-throughput technologies. LÄS MER