Sökning: "exocrine function"

Visar resultat 6 - 10 av 26 avhandlingar innehållade orden exocrine function.

  1. 6. Clinical consequences of pancreatic exocrine insufficiency

    Författare :Aleksandra Hedström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Chronic pancreatitis (CP) is characterized by a chronic inflammation with fibrosis and irreversible morphological changes that can result in permanent structural changes with a loss of exocrine and endocrine pancreas function. Exocrine dysfunction leads to reduced production of pancreatic digestive enzymes which is the reason of maldigestion and malabsorption of ingested nutrients like fats, microelements, vitamins and proteins which can lead to osteopathy. LÄS MER

  3. 7. Investigations into the distribution and function of nucleobindin 1

    Författare :Paul Williams; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nucleobindin proteins (NUCB1 and NUCB2) are both characterised by DNA- and calcium-binding motifs. The functionality of these motifs has been demonstrated, but has not yet led to the identification of a role for either protein. LÄS MER

  4. 8. Studies of the human pancreas to understand the pathologic events leading to type 1 diabetes

    Författare :Louise Granlund; Skog Oskar; Olle Korsgren; Marcus Lundberg; Per Andrén; Teresa Rodriguez-Calvo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreas; Type 1 Diabetes; Islets of Langerhans; Exocrine tissue; Acinar cells; Islet Microvasculature; Endocrine cells; Extra-islet cells; Insulin; Glucagon; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Type 1 diabetes (T1D) is classically described as a disease emanating from beta-cell loss, and as such, the beta cells have been the main target of investigation. However, recent years have witnessed a shift in perspective, with T1D being increasingly recognized as a condition that affects the entire pancreas. LÄS MER

  5. 9. FGFs and Wnts in pancreatic growth and β-cell function

    Författare :Stella Papadopoulou; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Wnt; FGF; pancreas; Notch; signal transduction; development; proliferation; progenitors; β-cells; feedback; GSIS; diabetes; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Mesenchymal-epithelial interactions are pivotal for proper pancreatic growth and development. The pancreatic progenitor cells present in the early pancreatic anlagen proliferate and eventually give rise to all pancreatic cell types. LÄS MER

  7. 10. Long-term effects of cholecystokinin on exocrine and endocrine pancreas

    Författare :Thomas Gasslander; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The gastrointestinal hormone cholecystokinin (CCK) is known to be oneof the most potent stimulators of pancreatic growth. CCK is alsosuggested to be an initiator and/or promotor of pancreatic carcinogenesis. LÄS MER