Sökning: "director"

Visar resultat 6 - 10 av 155 avhandlingar innehållade ordet director.

  1. 6. Pharmacometric Models for Antibody Drug Conjugates and Taxanes in HER2+ and HER2- Breast Cancer

    Författare :Brendan Bender; Lena Friberg; Mats Karlsson; Jin Jin; Oscar della Pasqua; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometric; PKPD; model; breast cancer; T-DM1; thrombocytopenia; hepatotoxiticy; HER2; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : In oncology, there is a need to optimize drug treatment for efficient eradication of tumors, minimization of adverse effects (AEs), and prolonging patient survival. Pharmacometric models can be developed to streamline information between drug development phases, describe and quantify response to treatment, and determine dose regimens that balance toxicity and efficacy. LÄS MER

  3. 7. Frustrated magnetism in icosahedral structures : The influence of order-disorder in quasicrystals and approximant crystals

    Författare :Fernand Denoel; Roland Mathieu; Marc de Boissieu; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; quasicrystals; approximant crystals; spin glasses; SQUID magnetometry; Physics with spec. in Atomic; Molecular and Condensed Matter Physics; Fysik med inriktning mot atom- molekyl- och kondenserande materiens fysik;

    Sammanfattning : This work will begin with an introduction to quasicrystals (QCs) and their structure, defining the unit cell-equivalent for icosahedral quasiperiodicity: a 3D tiling based on the golden ratio and aperiodic in all three dimensions. We briefly present the cut-and-project method used to generate QCs from a higher dimension hypercrystal, and how to build the 3D Penrose tilings, composed of the two golden rhombohedra. LÄS MER

  4. 8. Solitary waves and enhanced incoherent scatter ion lines

    Författare :Jonas Ekeberg; Lars Eliasson; Kristof Stasiewicz; Jan Trulsen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; plasma waves and instabilities; nonlinear phenomena; solitons and solitary waves; ionosphere; Sun: corona; incoherent scatter radar; MHD; plasmavågor och instabiliteter; ickelinjära fenomen; solitoner och solitära vågor; jonosfär; solen: korona; inkoherent spridningsradar; MHD; Geocosmophysics and plasma physics; Geokosmofysik och plasmafysik; Space physics; Rymdfysik; Plasma physics; Plasmafysik; Non-linear dynamics; chaos; Icke-linjär dynamik; kaos; fysik; Physics; rymd- och plasmafysik; Space and Plasma Physics;

    Sammanfattning : This thesis addresses solitary waves and their significance for auroral particle acceleration, coronal heating and incoherent scatter radar spectra. Solitary waves are formed due to a balance of nonlinear and dispersive effects. LÄS MER

  5. 9. Life-stowing from a Digital Media Perspective : Past, Present and Future

    Författare :Alberto Frigo; Stina Bengtson; Jay David Bolter; Södertörns högskola; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; life-stowing; tebahism; effortfull; life-logging; quantified self; selftracking; surveillance; sousveillance; archiving; syncretism; constructivist theory of perception; database aesthetics; Kritisk kulturteori; Critical and Cultural Theory;

    Sammanfattning : While both public opinion and scholars around the world are currently pointing out the danger of increasingly popular life-logging devices, this book articulates this debate by distinguishing between automatic and manual life-logging approaches. Since new definitions of life-logging have excluded the latter approach and have been mainly focused on effortless life-logging technologies such as Google Glass and Quantified Self applications in general, the second part of this thesis theoretically frames life-stowing. LÄS MER

  7. 10. Tamiflu in the Water : Resistance Dynamics of Influenza A Virus in Mallards Exposed to Oseltamivir

    Författare :Anna Gillman; Josef D Järhult; Björn Olsen; Shaman Muradrasoli; Elena Govorkova; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Influenza A virus; avian influenza; oseltamivir; neuraminidase inhibitors; resistance; environmental; Mallard; waterfowl; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The natural reservoir of influenza A virus (IAV) is wild waterfowl, and all human IAVs have their genetic origins from avian viruses. Neuraminidase inhibitors (NAIs) are currently the best drugs for treatment of human influenza; therefore, the orally available NAI oseltamivir (Tamiflu®) has been stockpiled worldwide as part of pandemic preparedness planning. LÄS MER