Sökning: "digital tablet"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden digital tablet.

1. 21. Mechanism-based modeling of biological processes involved in oral absorption

   Författare :Benjamin Guiastrennec; Mats O. Karlsson; Martin Bergstrand; Jörg Lippert; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; absorption; bile acids; enterohepatic circulation; food effect; gallbladder; in vitro in vivo correlation; NONMEM; pediatrics; pharmacometrics; tuberculosis; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. LÄS MER

3. 22. Separation of Pharmaceuticals by Capillary Electrophoresis using Partial Filling and Multiple-injections

   Författare :Henrik Lodén; Curt Pettersson; Torbjörn Arvidsson; Ahmad Amini; Morgan Stefansson; Uppsala universitet; []
   Nyckelord :Capillary Coating; Chiral Separation; Enantiomers; Mass-spectrometric Detection; Method Validation; Multiple-injection Capillary Zone Electrophoresis; Non-aqueous Capillary Electrophoresis; Organic Solvents; Pharmaceutical Analysis; Quantitative Analysis;

   Sammanfattning : Different multiple-injection methodologies and the partial filling technique (PFT) have been utilized for separation of pharmaceuticals by capillary elec-trophoresis. In multiple-injection capillary zone electrophoresis (MICZE), the samples and all standards, used for construction of the calibration curve, are analyzed within a single run. LÄS MER

4. 23. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

   Författare :Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. LÄS MER

5. 24. Identification of Viscoelastic Materials by Use of Wave Propagation Methods

   Författare :Saed Mousavi; Bengt Lundberg; Urmas Valdek; Janne Färm; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Engineering physics; Identification; Viscoelastic; Complex modulus; Complex Poisson s ratio; wave; Impact; Teknisk fysik; Engineering physics; Teknisk fysik;

   Sammanfattning : Complex moduli and Poisson’s ratio have been estimated using extensional and torsional wave experiments. The data were used for assessment of linearity and isotropy of two polymers, polymethyl methacrylate (PMMA) and polypropylene (PP). The responses of both materials were found to be close to linear and isotropic. LÄS MER

7. 25. Water-Induced Charge Transport in Microcrystalline Cellulose

   Författare :Martin Nilsson; Maria Strømme; Göran Alderborn; Jürgen Einfeldt; Uppsala universitet; []
   Nyckelord :Materials science; Materialvetenskap;

   Sammanfattning : Microcrystalline cellulose (MCC) is the most frequently used excipient for direct compaction of tablets within the pharmaceutical industry. It has earlier been indicated that the interactions between the hydration shell – surrounding the drug molecules in an MCC tablet – and the cellulose regulate the speed of the drug release process. LÄS MER