Sökning: "Jörg Lippert"

Hittade 1 avhandling innehållade orden Jörg Lippert.

1. 1. Mechanism-based modeling of biological processes involved in oral absorption

   Författare :Benjamin Guiastrennec; Mats O. Karlsson; Martin Bergstrand; Jörg Lippert; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; absorption; bile acids; enterohepatic circulation; food effect; gallbladder; in vitro in vivo correlation; NONMEM; pediatrics; pharmacometrics; tuberculosis; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics of the dosage form and the physico-chemical properties of the drug. This thesis primarily aimed to improve the mechanistic understanding and the predictability of processes involved in the absorption of orally administered drugs using a population modeling approach. LÄS MER