Sökning: "diabetes 2"

Visar resultat 16 - 20 av 1381 avhandlingar innehållade orden diabetes 2.

1. 16. Cardiovaskular risk factors and complications in type 1 and type 2 diabetes

   Författare :Katarina Eeg-Olofsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Cardiovascular diseases; Epidemiology;

   Sammanfattning : Patients with diabetes have increased risk of cardiovascular disease (CVD) and mortality compared to the general population. The aim of this work was to describe the clinical characteristics and risk factors in patients with type 1 diabetes, and also to investigate the association between glycaemic control and CVD in type 1 and type 2 diabetes, and to analyse the association between BMI, overweight and obesity, and CVD in type 2 diabetes. LÄS MER

3. 17. Brain function and glucocorticoids in obesity and type 2 diabetes including effects of lifestyle interventions

   Författare :Andreas Stomby; Tommy Olsson; Mats Ryberg; Carl-Johan Boraxbekk; Alasdair MacLullich; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; type 2 diabetes; glucocorticoid; cortisol; 11beta hydroxysteroid dehydrogenase type 1; episodic memory; functional magnetic resonance imaging; paleolithic diet; exercise; Internal Medicine; invärtesmedicin; medicin; Medicine;

   Sammanfattning : Background Obesity and associated metabolic dysregulation are linked to impaired cognitive function and alterations in brain structure, which increases the risk of age-related dementia. Increased glucocorticoid (GC) exposure may be a potential mediator of these negative effects on the brain. LÄS MER

4. 18. Genetic variants and the risk of type 2 diabetes

   Författare :Anna Jonsson; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin secretion; Type 2 diabetes; genome-wide association studies; genetic association;

   Sammanfattning : Type 2 diabetes is rapidly increasing worldwide thereby posing a severe burden on individual and public health. Although this increase can be ascribed to both genetic and environmental factors, until 2007, the genetic factors have been largely restricted to a few candidate genes based upon our limited knowledge of the pathogenesis of the disease. LÄS MER

5. 19. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine

   Författare :Klev Diamanti; Jan Komorowski; Claes Wadelius; Manfred Grabherr; Peter Spégel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; multi-omics; genomics; metabolomics; data science; machine learning; personalized medicine; Bioinformatics; Bioinformatik;

   Sammanfattning : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. LÄS MER

7. 20. DNA methylation patterns in human adipose tissue in relation to diet and type 2 diabetes

   Författare :Alexander Perfilyev; Diabetes - epigenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA Methylation; Adipose Tissue; Illumina 450k methylation array; type 2 diabetes;

   Sammanfattning : Type 2 diabetes (T2D) is a common metabolic disease and its prevalence is increasing worldwide. Adipose tissue plays an important role in metabolic processes. Environmental factors may affect metabolic phenotypes and epigenetics may mediate this influence. LÄS MER