Sökning: "cytotoxic drug development"

Visar resultat 16 - 20 av 53 avhandlingar innehållade orden cytotoxic drug development.

  1. 16. Targeting ALK and WIP1 : neuroblastoma precision medicine under development

    Författare :Diana Treis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma is the childhood solid tumor accountable for the largest number of deaths, calling for improved treatment. Some genetic alterations are considered crucial in driving initiation and progression of neuroblastoma. These are usually associated with poor prognosis and are viewed as potential therapeutic targets. LÄS MER

  3. 17. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

    Författare :Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. LÄS MER

  4. 18. Approaches to Treatment of Children with Advanced Neuroblastoma

    Författare :Ingrid Øra; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; drug resistance; hypoxia; apoptosis; arsenic trioxide; treatment; diagnosis; neuroblastoma; sympathetic nervous system; Pediatri; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

    Sammanfattning : Children with advanced neuroblastoma are at high risk for relapse of multidrug resistant disease, despite initial response to intensive multimodality treatment. Neuroblastomas have similarities with immature neuroblasts seen during embryonic development of the sympathetic nervous system (the origin of these tumors). LÄS MER

  5. 19. All-Photonic Control of Biorelevant Processes using Molecular Photoswitches and Caged Compounds

    Författare :Jesper Nilsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dithienylethene; azobenzene; drug release; kinase inhibitor; spiropyran; caged compound; live cell; spectroscopy; o-nitrobenzyl; photoswitch;

    Sammanfattning : The development of light-controlled molecular tools for in situ regulation of biological activity holds great promise e.g. for resolving dynamic aspects of cellular signal transduction and to overcome inherent pharmaceutic limitations such as poor drug selectivity. LÄS MER

  7. 20. Novel human in vitro systems for studies of drug inducted hepatotoxicity

    Författare :Louise Sivertsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug discovery, being one of the most common reasons for regulatory actions, including boxed warnings, restricted marketing and withdrawals of marketed drugs. LÄS MER