Sökning: "kinase inhibitor"
Visar resultat 1 - 5 av 336 avhandlingar innehållade orden kinase inhibitor.
1. Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors
Sammanfattning : Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong association with diseases, details of their physiologic and pathologic mechanisms remain at least partially unclear, especially the spatiotemporal dynamics of the signalling. LÄS MER
2. Synthesis of Novel Homoserine Analogues - Towards t he Development of Substrate-based Peptide Inhibitors of cAMP-dependent Protein Kinase
Sammanfattning : Protein kinases are enzymes that via phosphorylation of proteins/peptides regulate most aspects of cell functions and physiology. The enzymes transfer a -phosphoryl group from ATP to hydroxyl groups of Ser, Thr and Tyr residues in their substrates. LÄS MER
3. Aspects on long-term treatment with tyrosine kinase inhibitors in Chronic myeloid leukemia
Sammanfattning : Chronic myeloid leukemia (CML) is caused by the tyrosine kinase activity of the oncoprotein BCR-ABL. The introduction of tyrosine kinase inhibitors (TKIs) targeting BCR-ABL has profoundly changed the prognosis of CML. Currently, there are three TKIs approved for treatment of CML, imatinib, nilotinib and dasatinib. LÄS MER
4. Pharmaceutical Protection of Beta-Cells in Diabetes : Using Tyrosine Kinase Inhibition and NOX4 Inhibitors
Sammanfattning : Diabetes mellitus is a complex and heterogenous disease, with loss of beta-cell function and mass being a characteristic of not only type 1 diabetes (T1D), but also type 2 diabetes (T2D). In T1D, inappropriate inflammatory signaling is thought to participate in the autoimmune suppression and destruction of beta-cells. LÄS MER
5. The role of phosphatidylinositol 4-phosphate 5-kinase type І alpha (PIP5K1α) and utility of its inhibitor for targeting metastatic cancer
Sammanfattning : Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. LÄS MER