Sökning: "cyclophosphamide"

Visar resultat 11 - 15 av 54 avhandlingar innehållade ordet cyclophosphamide.

  1. 11. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Författare :Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. LÄS MER

  3. 12. Pharmacokinetics and Pharmacodynamics of Anti-Cancer Regimens : Emphasis on Busulphan and the Combination Therapies Epirubicin-Docetaxel and Fluorouracil-Epirubicin-Cyclophosphamide

    Författare :Marie Sandström; Alison H Thomson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmacognosy; farmakognosi;

    Sammanfattning : Although the main reason for the lack of distinct dose-response and -toxicity relationships for anti-cancer agents is due to variability in pharmacodynamics, variability in pharmacokinetics may also contribute. Hence, not only describing and quantifying the relationship between pharmacokinetics and dose-limiting toxicities, but characterising the pharmacokinetics and its associated variability are of obvious importance in the process of developing dosing strategies for anti-cancer regimens. LÄS MER

  4. 13. Cyclophosphamide and treosulfan in the conditioning regimen prior to allogeneic stem cell transplantation

    Författare :Fredrik Sjöö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Allogeneic stem cell transplantation (SCT) is a curative treatment for malignant and non-malignant diseases. However, transplantation related morbidity and mortality are major drawbacks affecting the survival and life quality of the patients. LÄS MER

  5. 14. Pathophysiological aspects of transplantation-related complications following busulphan/cyclophosphamide conditioning regimen in mouse model

    Författare :Sulaiman Al-Hashmi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Busulfan;

    Sammanfattning : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non-malignant disorders. However, transplantation related morbidity and mortality limit its use. The complications of the HSCT procedure can be caused by several factors including toxicity of the conditioning regimen and allogeneicity. LÄS MER

  7. 15. Muscarinic Receptors in the Urinary Bladder - The role of the urothelium regarding cholinergic and nitrergic effects in inflammation

    Författare :Michael Andersson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; urinary bladder; inflammation; cyclophosphamide-induced cystitis; muscarinic receptor; urothelium; nitric oxide; M5 receptor; rat; proliferation; micturition;

    Sammanfattning : Inflammation alters the functional properties of the urinary bladder. Interstitial cystitis (IC) is a chronic inflammatory syndrome in man that is characterized by urgency, frequency and visceral pain. LÄS MER