Sökning: "cyclophosphamide"

Visar resultat 6 - 10 av 54 avhandlingar innehållade ordet cyclophosphamide.

  1. 6. Radiotherapy in Early Breast Cancer

    Författare :Fredrika Killander; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pentoxifylline; cyclophosphamide; tamoxifen; side effects; randomised trial; Breast cancer; radiotherapy;

    Sammanfattning : Radiotherapy (RT) after mastectomy has been part of the treatment for early breast cancer since the 1940s. The treatment reduces the risk of loco-regional recurrences, but implies risk of late side effects that can begin decades after RT. LÄS MER

  3. 7. Optimization of cyclophosphamide therapy based on pharmacogenetics

    Författare :Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

    Sammanfattning : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. LÄS MER

  4. 8. Analytical and pharmacological studies of cyclophosphamide

    Författare :Rana Said; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pharmacokinetic and pharmacodynamic studies are an essential in order to achieve better treatment efficacy and less drug related toxicity. The kinetic studies depend on measuring the drug concentrations in body fluids. LÄS MER

  5. 9. Pharmacogenetic and pharmacokinetic studies of cyclophosphamide : in cell, animal and human

    Författare :Hanjing Xie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cyclophosphamide; Cytochrome P450; Metabolism; Pharmacokinetics; 4Hydroxycyclophosphamide;

    Sammanfattning : Cyclophosphamide (CPA) is widely used anti-cancer drug that has to be catalyzed by the cytochrome P450 (CYP) enzyme 2B6 as well as some other CYPs to exert its cytotoxic activity. A high degree of interindividual variation in CPA kinetics has been reported in both children and adult patients, which may be due to several factors such as concomitantly used drugs, variation in physiological status of individual patients and genetic polymorphism of the CYP enzymes. LÄS MER

  7. 10. Purinergic effects in the rat urinary bladder : Functional studies of cyclophosphamide treatment on afferent and efferent mechanisms

    Författare :Patrik Aronsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptors; purinergic; urinary bladder; purinoceptor; cystitis prevention; detrusor; bladder function; ATP; adenosine; nitric oxide;

    Sammanfattning : .... LÄS MER