Avancerad sökning

Hittade 4 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Responses of fibroblasts and chondrosarcoma cells to mechanical and chemical stimuli

    Författare :Juha Piltti; Mikko Lammi; Jukka Häyrinen; Frank Beier; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rho-kinase inhibition; Y-27632; hypoxia; cyclic stretching; human chondrosarcoma 2 8 cells; chondrocyte phenotype; fibroblasts; proteomics; protein pathway analytics; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Osteoarthritis is an inflammation-related disease that progressively destroys joint cartilage. This disease causes pain and stiffness of the joints, and at advanced stages, limitations to the movement or bending of injured joints. Therefore, it often restricts daily activities and the ability to work. LÄS MER

  3. 2. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

    Författare :Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

    Sammanfattning : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. LÄS MER

  4. 3. Vibrational Sum Frequency and Infrared Reflection/Absorption Spectroscopy Studies of the Air/Liquid and Liquid/Metal Interfaces

    Författare :Magnus Johnson; Christofer Leygraf; Andrew Gewirth; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Corrosion science; laser spectroscopy; nonlinear optics; Materials science; Teknisk materialvetenskap;

    Sammanfattning : Atmospheric corrosion, the most common form of metal corrosion, occurs within the interfacial region between a solid, and the surrounding atmosphere. In fact three phases and two interfaces are involved: the gas, a thin liquid layer, a solid, the gas/liquid and the liquid/solid interfaces. LÄS MER

  5. 4. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER