Sökning: "chondrocyte phenotype"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden chondrocyte phenotype.
1. Studies on chondrocyte integrins and mechanical signaling
Sammanfattning : Integrins are a family of cell surface receptors known to bind matrix proteins and to mediate signals such as mechanical signals between the cell and the surrounding matrix. We have studied integrins that are expressed by chondrocytes, with specific focus on the integrins that interact with the cartilage matrix protein collagen type II. LÄS MER
2. Studies on various culture systems for chondrocytes and osteoblasts
Sammanfattning : Osteoarthritis and osteochondral defects are ailments that are increasing in frequency as the lifespan of the population increases and sedentary lifestyle becomes more common. Osteoarthritis is an inflammatory disease that causes the progressive degeneration of articular surfaces and the underlying bone. LÄS MER
3. Responses of fibroblasts and chondrosarcoma cells to mechanical and chemical stimuli
Sammanfattning : Osteoarthritis is an inflammation-related disease that progressively destroys joint cartilage. This disease causes pain and stiffness of the joints, and at advanced stages, limitations to the movement or bending of injured joints. Therefore, it often restricts daily activities and the ability to work. LÄS MER
4. Chondrocyte and extracellular matrix alterations in equine cartilage during development and inflammation
Sammanfattning : Osteoarthritis (OA) is a disease involving inflammation and subsequent degeneration of joint tissues. The disease progresses with time-dependent stages of degeneration, loss and remodelling of the extracellular matrix (ECM) of articular cartilage, and phenotypical changes in the chondrocytes. LÄS MER
5. Biodegradable gelatin microcarriers in tissue engineering : In vitro studies on cartilage and bone
Sammanfattning : Tissue engineering is a multidisciplinary field that combines cells, biomaterial scaffolds and environmental factors to achieve functional tissue repair. This thesis focuses on the use of macroporous gelatin microcarriers as scaffolds in tissue engineering applications, with a special focus on cartilage and bone formation by human adult cells in vitro. LÄS MER