Sökning: "IGFBPs"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet IGFBPs.

  1. 1. Regulation of insulin-like growth factor-II in human liver

    Författare :Henrik von Horn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IG17-II; IGF2; IGFBPs; liver; hepatoblastoma; GH; hypoxia;

    Sammanfattning : Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented in conditions associated with elevated IGF-II precursor forms in the circulation. LÄS MER

  3. 2. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  4. 3. Regulation and actions of insulin-like growth factor binding proteins in vascular smooth muscle cells

    Författare :Thomas Gustafsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor-I (IGF-I) has multiple actions on vascular smooth muscle cell (VSMCs) function. In the circulation and in extracellular fluids, IGF-I is complexed to high affinity IGF-binding proteins (IGFBPs), which modulate IGF-I bioactivity. The present study focused on expression and regulation of IGFBPs in VSMCs. LÄS MER

  5. 4. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

    Författare :Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Insulin-like growth factor;

    Sammanfattning : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. LÄS MER

  7. 5. The IGF-IGFBP system in aerobic exercise : with focus on skeletal muscle

    Författare :Ulrika Berg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF-I; IGFBP-1; microdialysis; exercise; IL-6; calpain;

    Sammanfattning : Activity induced skeletal muscle adaptation has been suggested to be mediated largely by intrinsic factors, such as insulin-like growth factor (IGF)-I. IGF-I stimulates muscle glucose and amino acid uptake and promotes anabolism. LÄS MER