Sökning: "PTHrP"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet PTHrP.

  1. 1. Prognostic factors in renal cell carcinoma : evaluation of erythropoietin and its receptor, carbonic anhydrase IX, parathyroid hormone-related protein and osteopontin

    Författare :Karin Papworth; Torgny Rasmuson; Börje Ljungberg; Kjell Grankvist; Sten Nilsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; EPO; EPO-R; CA IX; PTHrP; OPN; prognosis; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : A prognostic factor is a marker or a feature that can be used to estimate the risk of recurrence of disease, metastatic spread and clinical outcome. Despite intensive search for more sophisticated markers in renal cell carcinoma (RCC), few have added prognostic information to earlier described factors like stage of disease, nuclear grade, tumour type, and in metastatic disease; performance status, anaemia, hypercalcaemia and increased erythrocyte sedimentation. LÄS MER

  3. 2. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

  4. 3. Calcium transport across the human placenta. The activity, expression and regulation of Ca2+ ATPase in normal and complicated pregnancies

    Författare :Hilja Strid; Göteborgs universitet; []
    Nyckelord :fetal growth; placental transport; human; pregnancy PTHrP 38-94 ; intrauterine growth restriction; diabetes; calcium;

    Sammanfattning : .... LÄS MER

  5. 4. The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin

    Författare :Alena Lagumdzija; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :h0B; SaOS-2; OXT; AVP; IGF-I; PTH; PTHrP; eNOSKO;

    Sammanfattning : The nonapeptides oxytocin (OXT) and vasopressin (AVP) are mainly produced in the hypothalamus and released into the circulation through the neurohypophysis. Recently, an OXT-receptor was demonstrated in human osteoblast-like (hOB) cells, and it has been suggested that patients with central diabetes insipidus (deficiency of AVP) have decreased bone mass. LÄS MER

  7. 5. Physiological and clinical studies of calcium-regulating hormones calcitonin and parathyroid hormone-related protein

    Författare :Haiqin Rong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bone metabolism; breast cancer; calcitonin; calcium; exercise; lanthanide; milk; neonate; osteoporosis; parathyroid hormone-related protein; parturition; polymerase chain reaction; time-resolved fluorometry;

    Sammanfattning : The present studies were performed to elucidate several physiological and clinical questions of calcitonin (CT) and parathyroid hormone-related protein (PTHrP) such as: a) Does age influence the basal and calcium-stimulated levels and circulating molecular forms of CT in healthy females? b) Are osteoporotic patients lacking circulating monomeric CT? c) How is salmon CT (sCT) absorbed and cleared during treatment of diseases? d) Is there any effect of acute physical activity on circulating CT, PTH, PTHrP and bone metabolic markers? e) Is there an absorbance of PTHrP in milk by the neonate? and f) Are there any interactions between CT and PTHrP? In addition, by use of time-resolved dissociation and enhancement lanthanide fluorometry, the effort was put to develop two-site immunofluorometric assays (IFMA) for sCT and PTHrP as well as a quantitative competitive PCR (QC-PCR) for measuring PTHrP mRNA and use these methods in some of the investigations. Heterogeneity of CT forms in serum was disclosed after immunoextraction, fast protein liquid chromatography (FPLC) and radioimmunoassay (RIA) in healthy females and osteoporotic patients. LÄS MER