Sökning: "copper-binding"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet copper-binding.

  1. 1. COPPER BINDING PROTEINS IN BREAST CANCER : CELLULAR AND MOLECULAR MECHANISMS

    Författare :Xiaolu Zhang; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atox1; Memo1; cell migration; breast cancer; copper; ROS;

    Sammanfattning : Cancer is one of the leading causes of human death. However, the mechanisms governing cancer are still not fully understood. Elevated levels of copper (Cu) have been observed in both cancerous tissues and the serum of cancer patients. LÄS MER

  3. 2. Structure and Dynamics of the Copper-binding Octapeptide Region in the Human Prion Protein

    Författare :Eva-Stina Riihimäki; Lars Kloo; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; prion protein; copper; molecular dynamics simulation; solvation model; metal ions; coordination; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : The copper-binding ability of the prion protein may be closely connected to its function. Identifying the exact function of the prion protein can clarify the underlying mechanism in prion diseases. In this work, the copper-binding octapeptide region in the human prion protein has been studied. LÄS MER

  4. 3. Studies on spinach plastocyanin and mutants : Expression in Escherichia coli, folding and function

    Författare :Mikael Ejdebäck; Örjan Hansson; Miguel A. De la Rosa; Göteborgs Universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; plastocyanin; electron transfer; copper; protein-protein interactions; protein expression; folding; site-directed mutagenesis; NMR; Naturvetenskap; Natural sciences;

    Sammanfattning : Photosynthesis is a process in which photons from sunlight excite chlorophylls in the thylakoid membranes of plants, algae and cyanobacteria. The photo-oxidised reaction centre chlorophyll P700 is re-reduced by an electron transferred from the soluble, blue copper protein plastocyanin. LÄS MER

  5. 4. A Theoretical Investigation of the Octapeptide Region in the Human Prion Protein

    Författare :Eva-Stina Riihimäki; Lars Kloo; José Manuel Martínez; Francisco Javier Luque Garriga; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; prion protein; copper; octapeptide; structure; force field parameters; coordination; non-periodic boundary conditions; Inorganic chemistry; Oorganisk kemi;

    Sammanfattning : Den kopparbindande egenskapen hos prionproteiner är sannolikt kopplad till proteinets funtion. Det mänskliga prionproteinet innehåller ett kopparbindande oktapeptidområde, där PHGGGWGQ-sekvensen upprepas fyra gånger i följd. LÄS MER

  7. 5. Protein Engineering on Azurin. Expression Mutagenesis and Characterisation of Copper Site Mutants

    Författare :B Göran Karlsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; EPR spectroscopy; cassette mutagenesis; optical spectroscopy; amino acid exchange; Escherichia coli; electron transfer; reduction; azurin;

    Sammanfattning : Azurin belongs to a family of small blue copper proteins or cupredoxins which participate in electron transfer processes in plants and bacteria. The type 1 copper site in these proteins is characterised by an intense blue colour, a narrow hyperfine coupling in the EPR signal and, generally, a high reduction potential. LÄS MER