Sökning: "B Göran Karlsson"

Hittade 4 avhandlingar innehållade orden B Göran Karlsson.

  1. 1. Protein Engineering on Azurin. Expression Mutagenesis and Characterisation of Copper Site Mutants

    Författare :B Göran Karlsson; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; EPR spectroscopy; cassette mutagenesis; optical spectroscopy; amino acid exchange; Escherichia coli; electron transfer; reduction; azurin;

    Sammanfattning : Azurin belongs to a family of small blue copper proteins or cupredoxins which participate in electron transfer processes in plants and bacteria. The type 1 copper site in these proteins is characterised by an intense blue colour, a narrow hyperfine coupling in the EPR signal and, generally, a high reduction potential. LÄS MER

  3. 2. Integrating domain knowledge into deep learning : Increasing model performance through human expertise

    Författare :Niclas Ståhl; Göran Falkman; Alexander Karlsson; Gunnar Mathiason; Jonas Boström; Keith Downing; Högskolan i Skövde; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; INF301 Data Science; INF301 Data Science; Skövde Artificial Intelligence Lab SAIL ; Skövde Artificial Intelligence Lab SAIL ;

    Sammanfattning : The research in this thesis is focused on how deep learning models can be designed and implemented to better emulate and integrate the heuristic reasoning process of human experts. Several case studies, within the domains of steel making and drug discovery, are conducted in order to evaluate the performance of these models, in comparison to models that do not consider human expert knowledge from the targeted domain. LÄS MER

  4. 3. Telomere length as prognostic parameter in chronic lymphocytic leukemia

    Författare :Pawel Grabowski; Göran Roos; Ylva Paulsson Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; chronic lymphocytic leukemia; prognosis; longitudinal sampling; genomic aberrations; IGHV; CD38; ZAP70; prognostic factors; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. LÄS MER

  5. 4. Remembering in Alzheimer's disease : utilization of cognitive support

    Författare :Agneta Herlitz; Lars-Göran Nilsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Dementia; Memory; Episodic memory; Semantic memory; Severity of dementia; Alzheimers sjukdom; demens; minne;

    Sammanfattning : The aim of the present doctoral thesis was to investigate the ability of patients with Alzheimer's disease (AD) to utilize cognitive support in order to improve episodic remembering. A review of previous research indicated that most studies have failed to find beneficial effects of encoding support on memory in AD patients. LÄS MER