Sökning: "Eva-Stina Riihimäki"

Hittade 2 avhandlingar innehållade orden Eva-Stina Riihimäki.

1. 1. A Theoretical Investigation of the Octapeptide Region in the Human Prion Protein

   Författare :Eva-Stina Riihimäki; Lars Kloo; José Manuel Martínez; Francisco Javier Luque Garriga; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; prion protein; copper; octapeptide; structure; force field parameters; coordination; non-periodic boundary conditions; Inorganic chemistry; Oorganisk kemi;

   Sammanfattning : Den kopparbindande egenskapen hos prionproteiner är sannolikt kopplad till proteinets funtion. Det mänskliga prionproteinet innehåller ett kopparbindande oktapeptidområde, där PHGGGWGQ-sekvensen upprepas fyra gånger i följd. LÄS MER

3. 2. Structure and Dynamics of the Copper-binding Octapeptide Region in the Human Prion Protein

   Författare :Eva-Stina Riihimäki; Lars Kloo; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; prion protein; copper; molecular dynamics simulation; solvation model; metal ions; coordination; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi;

   Sammanfattning : The copper-binding ability of the prion protein may be closely connected to its function. Identifying the exact function of the prion protein can clarify the underlying mechanism in prion diseases. In this work, the copper-binding octapeptide region in the human prion protein has been studied. LÄS MER