Sökning: "Post translational modifications"

Visar resultat 1 - 5 av 121 avhandlingar innehållade orden Post translational modifications.

  1. 1. Compact-disc microfluidic methods for characterization of therapeutic antibodies : Analysis of post-translational modifications

    Författare :Thi Thuy Tran; Gunnar Thorsén; McLean John; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microfluidic CD; therapeutic antibodies; post-translational modifications; glycosylation profiling; multivariate statistical analysis; MALDI-MS; Analytical Chemistry; analytisk kemi;

    Sammanfattning : Characterization of post-translational modifications (PTMs) of therapeutic proteins is very important during the bioprocess development to maintain desired product quality and during the submission process to regulatory authorities for product approval. Monitoring glycosylation in pharmacokinetic studies can be useful to evaluate the dependence of clearance rates on different glycoforms. LÄS MER

  3. 2. Post-translational modifications of eukaryotic protein synthesis elongation factor-2 : a study in relation to ageing

    Författare :Bent Riis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytologi; Cellbiologi;

    Sammanfattning : .... LÄS MER

  4. 3. Regulation of TGF-β Signaling by Post-Translational Modifications

    Författare :Peter Lönn; Aristidis Moustakas; Carl-Henrik Heldin; Petra Knaus; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TGF-β; Smad; PARP-1; PARG; ALK5; SIK; signal transduction; transcription; post-translational modification; phosphorylation; ubiquitin; ADP-ribosylation; DNA-binding; receptor degradation; Cell and molecular biology; Cell- och molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. LÄS MER

  5. 4. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1

    Författare :Cecilia Ström; Thomas Helleday; Hans Krokan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; base excision repair; single-strand break repair; PARP-1; CK2; XRCC1; mammalian cells; Cell and molecular biology; Cell- och molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. LÄS MER

  7. 5. New fractionation tools targeting elusive post-translational modifications

    Författare :Celina Wierzbicka; Malmö högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular imprinting; Molecular recognition; Phosphopeptides; Proteomics; Phosphotyrosine; Phosphohistidine;

    Sammanfattning : Protein phosphorylation is a reversible post-translational modification (PTM)playing a central role in numerous biological events including disease pathogenesis.Thus, the analysis of phosphoproteome is crucial for understandingcellular regulation processes and can facilitate the development of new diagnosticand therapeutic tools. LÄS MER