Sökning: "collagen gel contraction"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden collagen gel contraction.

  1. 1. Extracellular Matrix and Actin Cytoskeleton - the Control Unit of Interstitial Fluid Volume

    Författare :Vahid Reyhani; Kristofer Rubin; Markella Ponticos; Uppsala universitet; []
    Nyckelord :Collagen; fibrin; integrins; PDGF-BB; gel contraction; fluid homeostasis; interstitial fluid pressure; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : The regulation of fluid (water) volume in the body is crucial for tissue homeostasis. The interstitial fluid, which comprises almost 20% of the body fluid, is stored in the loose connective tissue and its volume is actively regulated by components of this tissue. LÄS MER

  3. 2. Integrin αVβ3-Directed Contraction by Connective Tissue Cells : Role in Control of Interstitial Fluid Pressure and Modulation by Bacterial Proteins

    Författare :Åsa Lidén; Kristofer Rubin; Karl-Eric Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; interstitial fluid pressure; collagen gel contraction; integrin αVβ3; septic shock; fibronectin; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : This thesis aimed at studying mechanisms involved in control of tissue fluid homeostasis during inflammation.The interstitial fluid pressure (PIF) is of importance for control of tissue fluid balance. A lowering of PIF in vivo will result in a transport of fluid from the circulation into the tissue, leading to edema. LÄS MER

  4. 3. Functional Studies of Collagen-Binding Integrins α2β1 and α11β1 : Interplay between Integrins and Platelet-Derived Growth Factor Receptors

    Författare :Gunilla Grundström; Kristofer Rubin; Karl-Eric Magnusson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Integrins are heterodimeric cell surface receptors, composed of an α- and a β-subunit, which mediate cell-extracellular matrix (ECM) interactions. Integrins mediate intracellular signals in response to extracellular stimuli, and cooperate with growth factor and other cytokine receptors. LÄS MER

  5. 4. Collagen-binding integrin α2β1 activity in vivo and in vitro : Effects of platelet-derived growth factor-BB

    Författare :Karina Åhlén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin α2β1; PDGF-BB; fibroblast; interstitial fluid pressure; cytoskeletal interaction; phosphatidylinositol 3-kinase; [Ca2 ]i; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : The expression of integrins by two cell clones from a rat colon carcinoma was investigated. Cloned cells that gave rise to regressive tumors, but not cells that gave rise to progressive, lethal, tumors, adhered to interstitial collagens through the integrin α2β1, although both cell types expressed it. LÄS MER

  7. 5. Intra- and Extracellular Modulation of Integrin-directed Connective Tissue Cell Contraction

    Författare :Tijs van Wieringen; Kristofer Rubin; Anders Arner; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Interstitial fluid pressure; PDGF-BB; bacterial proteins; αVβ3 integrin; cytoskeleton; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : All blood vessels in the microvasculature are embedded in loose connective tissue, which regulates the transport of fluid to and from tissues. The intersti-tial fluid pressure (IFP) is one of the forces that control this transport. LÄS MER