Sökning: "clonal complex"

Visar resultat 16 - 20 av 51 avhandlingar innehållade orden clonal complex.

  1. 16. Genetic Characterization and Identification of Novel Treatment Targets in Anaplastic Thyroid Carcinoma

    Författare :Naveen Ravi; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic thyroid cancer; copy number alterations; somatic mutations; mutational signatures; DNA methylation analysis; Gene expression analysis;

    Sammanfattning : Anaplastic thyroid cancer (ATC) is a rare and highly aggressive thyroid malignancy, usually resistant to conventional therapeutic strategies. The prognosis of ATC is extremely poor with a median survival rate of 6 months. Current treatment therapy includes surgical resection in combination with external radiotherapy and chemotherapy. LÄS MER

  3. 17. Mast cell activation disorders : a liaison between anaphylaxis and mastocytosis

    Författare :Theo Gülen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The term mast cell activation disorders (MCAD) comprises a broad spectrum of heterogeneous conditions, such as mastocytosis, characterized by inappropriate mast cell activation/accumulation. The patients present with protean clinical manifestations and severity grade of symptoms may vary from case-to-case. LÄS MER

  4. 18. Genetic and epigenetic influence on oxidative phosphorylation, islet function and type 2 diabetes in humans

    Författare :Anders H Olsson; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Genetics; Epigenetics; Human Pancreatic Islets; Oxidative Phosphorylation; Insulin Secretion;

    Sammanfattning : The prevalence of type 2 diabetes (T2D) is increasing worldwide. T2D is a heterogeneous disease caused by a complex interplay between multiple genetic, epigenetic and non-genetic factors. The disease is characterised by impaired insulin secretion from pancreatic β-cells and insulin resistance in peripheral tissues. LÄS MER

  5. 19. Epidemiology and population structure of Campylobacter jejuni and related organisms in wild birds

    Författare :Jonas Waldenström; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; epidemiology; Campylobacter lari; population structure; Helicobacter canadensis; Ecology; Parasitology human and animal ; Animal ecology; Djurekologi; Parasitologi människa och djur ; migration; Ekologi; wild birds; Sweden; Campylobacter jejuni;

    Sammanfattning : Campylobacter jejuni is one of the most common causes to bacterial gastroenteritis in the industrialised world. Also other species of the Campylobacter genus give rise to human infections. C. jejuni occurs in many different animal hosts and can be isolated from water sources. LÄS MER

  7. 20. Theoretical modelling of LA-MRSA in Swedish pig production

    Författare :Krista Tuominen; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Antimicrobial resistance is a threat to global health. Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is a category of multiresistant bacteria that primarily colonises livestock animals. While pigs are considered its main reservoir, LA-MRSA is zoonotic and causes an occupational risk to those working with livestock. LÄS MER