Avancerad sökning

Visar resultat 1 - 5 av 51 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Invasive Pneumococcal Infections

    Författare :Erik Backhaus; Göteborgs universitet; []
    Nyckelord :Streptococcus pneumoniae; epidemiology; risk factors; pneumonia; meningitis; serotype; clonal complex;

    Sammanfattning : Streptococcus pneumoniae is a major cause of disease, ranging from uncomplicated respiratory infections to severe invasive pneumococcal disease (IPD), including bacteraemic pneumonia, septicaemia with unknown focus and meningitis. Case fatality rate (CFR) remains high and antibiotic resistance is increasing globally. S. LÄS MER

  3. 2. Phenotypic antibody discovery and mining of complex antibody libraries

    Författare :Anne Ljungars; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibody discovery; Phage display; Phenotypic screening; Cell selection; Deep mining; Complex phage pools;

    Sammanfattning : Therapeutic antibodies are the fastest growing class of drugs but suffer from a crowded target-space where many antibodies, against a few targets, are developed in parallel. The aim of this thesis is to find methods to enable discovery of novel antibody-target combinations and thereby increase the target-space. LÄS MER

  4. 3. Clonal structures and cell interactions in cancer

    Författare :Nathanael Andrews; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite sharing an identical genome, cells of higher order multicellular organisms display a large degree of phenotypic diversity. This diversity is maintained by a sophisticated regulatory machinery that integrates information from both intrinsic and extrinsic factors, ultimately coordinating the appropriate gene expression. LÄS MER

  5. 4. Structural Basis of Immune Receptor Binding by Staphylococcal Superantigens

    Författare :Karin Rödström; Medicinsk strukturbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Superantigen; X-ray Crystallography; T cell receptor; Major histocompatibility complex;

    Sammanfattning : Superantigens (SAgs) are toxins capable of inducing a massive immune response, leading to severe disease. They are secreted by the bacteria Staphylococcus aureus and Streptococcus pyogenes, which produce the staphylococcal enterotoxins and streptococcal pyogenic exotoxins, respectively. LÄS MER

  7. 5. Molecular epidemiology of streptococcus agalactiae : mobile elements as genetic markers

    Författare :Shi-Lu Luan; Mari Norgren; Barbara Spellerberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus agalactiae; group II intron GBSi1 ; multilocus sequence typing; capsular serotype; population structure; Clinical bacteriology; Klinisk bakteriologi;

    Sammanfattning : Streptococcus agalactiae, also designated group B streptococcus (GBS), is a Gram-positive coccus, and it is an important pathogen that causes invasive disease in neonates, pregnant adults, and non-pregnant adults with predisposing conditions. The group II intron GBSi1 is one of the major mobile genetic elements identified in S. agalactiae. LÄS MER