Sökning: "cell fate"

Visar resultat 21 - 25 av 267 avhandlingar innehållade orden cell fate.

  1. 21. Syndecan - Regulation and Function of its Glycosaminoglycan Chains

    Författare :Anna S. Eriksson; Dorothe Spillmann; Catherine Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulfate; chondroitin sulfate; integrin; cell motility; fibroblast growth factor signaling; pharyngeal cartilage; biosynthesis regulation; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The cell surface is an active area where extracellular molecules meet their receptors and affect the cellular fate by inducing for example cell proliferation and adhesion. Syndecans and integrins are two transmembrane molecules that have been suggested to fine-tune these activities, possibly in cooperation. Syndecans are proteoglycans, i.e. LÄS MER

  3. 22. Integration of Electrospun Materials in Microelectronic and Biomedical Applications

    Författare :Björn Carlberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; microstructure; electrospinning; interpenetrating phase; stem cell; photolithography; patterning; thermal management; thermal interface material; scaffold;

    Sammanfattning : This thesis demonstrates the use of electrospinning and the novel properties of electrospunmaterials in two fields.The microelectronics industry has identified thermal interface materials as one of themajor bottlenecks hindering further integration at packaging level. LÄS MER

  4. 23. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

  5. 24. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

    Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER

  7. 25. Stem cell fate regulation: computational modeling in the hematopoietic system

    Författare :José Teles; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stochastic modeling; dynamical modeling; gene regulation; hematopoiesis; cell fate; stem cells; Fysicumarkivet A:2012:Teles;

    Sammanfattning : The ability to sense the surrounding environment and respond to external fluctuations is a fundamental property of cells, the basic unit of life. Although cells can be very different in their composition and structure, they all have specialized molecular mechanisms that allow them to adapt to their environment, by coordinating gene expression and protein production. LÄS MER