Sökning: "TRAIL-R"

Hittade 2 avhandlingar innehållade ordet TRAIL-R.

  1. 1. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

  3. 2. Dysregulation of receptor induced apoptosis during human leishmaniasis : a possible mechanism of skin ulceration

    Författare :Liv Eidsmo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cutaneous leishmaniasis; visceral leishmaniasis; Death Receptors; Fas; FasL; Apoptosis;

    Sammanfattning : Leishmaniasis is endemic in 88 countries and 12 million people per year have been estimated to be at risk of infection. The causative agent, the protozoan Leishmania, is spread by sand-flies and infects macrophages in the mammalian host. Leishmaniasis in humans form a spectrum of clinical presentations. In cutaneous leishmaniasis (CL) caused by L. LÄS MER