Sökning: "Yap Taz"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Yap Taz.

  1. 1. Role of the co-transcriptional regulators Yap/Taz in the normal and fibrotic lung epithelia

    Författare :Hani N. Alsafadi; NanoLund: Centre for Nanoscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lung Epithelium; idiopathic pulmonary fibrosis IPF ; Developmental pathways; Hippo Signaling; Yap Taz; transcription factors; 3D culture models; ;

    Sammanfattning : Idiopathic pulmonary fibrosis (IPF) is a fatal disease that exhibits patterns of usual interstitial pneumonia with honeycombing. IPF is characterized by damaged distal lung epithelium with excessive tissue scarring and extracellular matrix remodeling. The etiology of IPF is unknown and current therapies cannot end or reverse disease progression. LÄS MER

  3. 2. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

  4. 3. Mechanosensitive transcriptional regulation of gene expression in smooth muscle. Implications for health and disease

    Författare :Fatima Daoud; Molekylär kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; smooth muscle cell; phenotypic modulation; Yap Taz; MRTFA; hypertension; atherosclerosis;

    Sammanfattning : Smooth muscle participates in forming the wall of hollow organs, tracts, and blood vessels. Therefore, it plays a critical role in mediating vital functions in the body including regulation of blood pressure. LÄS MER

  5. 4. Genetic modeling of the Hippo pathway in hematopoietic stem cells

    Författare :Lina Jansson; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cells; hematopoiesis; Hippo pathway; hematopoietic stem cells;

    Sammanfattning : Hematopoiesis is the process of blood formation from a limited pool of hematopoietic stem cells (HSCs). These rare stem cells can both self-renew to maintain the HSC pool, and differentiate to continuously replenish lost blood cells. The mechanisms of HSC regulation are not fully known. LÄS MER

  7. 5. Novel insights into dishevelled and frizzled function

    Författare :Jana Valnohova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The formation of a multicellular body during embryonic development is one of the most fascinating processes in biology. The cells are in constant communication and must be precisely coordinated. Several essential signalling pathways have been identified in cell-to-cell signal transmission. LÄS MER