Sökning: "bone marrow transplantation"

Visar resultat 26 - 30 av 139 avhandlingar innehållade orden bone marrow transplantation.

1. 26. Human Dendritic Cells and the Regulation of Allergic Immune Responses

   Författare :Malin Lindstedt; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; transplantation; Immunologi; serologi; Immunology; allergic rhinitis; inflammation; transcriptional profiling; T cells; Dendritic cells; microarray;

   Sammanfattning : Dendritic cells (DC) are a heterogeneous lineage of bone-marrow-derived leukocytes that serve as the link between innate and adaptive immunity. They are professional antigen-presenting cells that play an important protective and regulatory role in both health and disease. LÄS MER

3. 27. Understanding the role of bone marrow niche in myeloid malignancies

   Författare :Monika Dolinska; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Normal hematopoiesis is generated and maintained by rare hematopoietic stem cells (HSCs) through their capacity to self-renew and differentiate. This process is rigorously controlled, both by HSC-intrinsic molecular programs and extrinsic signals emitted by the local bone marrow (BM) microenvironment, the so-called HSC niche. LÄS MER

4. 28. Expression profiling using manifold supports

   Författare :Anette Hagberg; Joakim Lundeberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mRNA; expression; minimal residual disease MRD ; chronic myeloid leukemia CML ; recombinant human erythropoietin r-HuEpo ; anemia; insulin dependent diabetes mellitus IDDM ; transplantation; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Sammanfattning : Analyses of mRNA provides a condensed view of gene structure and quantitative analysis can reveal the induction of physiological or pathological gene expression programs. This thesis describes a new method for mRNA isolation, followed by sensitive real time detection via polymerase chain reaction (PCR), in order to quantitate transcripts of interest. LÄS MER

5. 29. To be or not to be, unraveling molecular mechanisms for lineage decisions in developing blood cells

   Författare :Robert Månsson; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; common lymphoid precursor CLP ; early B-cell factor 1 EBF1 ; B-cell; Stemcell; hematopoiesis; extracellulära vätskor; Immunology; serology; transplantation; Immunologi; serologi;

   Sammanfattning : All hematopoietic cells originate from hematopoietic stem cells (HSC) residing in the BM. The process of differentiation, through which HSCs generate progenitors and subsequently mature blood cells has been extensively studied but many of the regulatory mechanisms involved remains elusive. LÄS MER

7. 30. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease

   Författare :Lena Brånén; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; cell replication; Cardiovascular system; Kardiovaskulära systemet; spindle-shaped; epithelioid; smooth muscle cells; periadventitial cuff injury; sTNF-R1; bone marrow transplantation; chimeric fusion protein; atherogenic diet; ApoE; TNF-a; genetically altered mice; en face preparation; atherosclerosis; neointimal hyperplasia;

   Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER