Sökning: "bacterial toxins"

Visar resultat 6 - 10 av 62 avhandlingar innehållade orden bacterial toxins.

  1. 6. Novel signaling pathways : induced by bacterial toxins in eukaryotic cells

    Författare :Camilla Oxhamre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation is the process by which the host counteracts microbes that are constantly exposing the human body. These microbes rarely cause disease, due to the effective defense mechanisms of the host immune system. Although inflammation is essential for preventing infections, it can also damage the host. LÄS MER

  3. 7. Towards novel antibacterials : Synthesis and identification of natural product inspired inhibitors of Chlamydia trachomatis and development of chemical probes targeting virulence of Pseudomonas aeruginosa

    Författare :Michael Saleeb; Mikael Elofsson; Anna Linusson Jonsson; Andreas Kirschning; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibacterials; antibiotics; small molecules; natural products; benzofuran; dihydrobenzofuran; the type III secretion system; Pseudomonas aeruginosa; Chlamydia trachomatis; phenotypic screening; high-throughput screening; surface plasmon resonance; drug discovery; bacterial toxins; enzyme inhibitors; organisk kemi; Organic Chemistry;

    Sammanfattning : Antibiotic resistance has evolved significantly to become one of the serious threats to public health today. Yet, the pipeline of new antibiotics is drying up and is lagging behind the challenging needs. LÄS MER

  4. 8. Regulatory mechanisms involved in pathoadaptation of extraintestinal pathogenic Escherichia coli

    Författare :Nikola Zlatkov; Bernt Eric Uhlin; Åke Forsberg; Sun Nyunt Wai; Eliora Ron; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExPEC; PAIs; pathoadaptation; citrate; metabolism; filamentation; toxins; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Sammanfattning : Establishment of commensal bacteria within a new niche of their host usually promotes the transition from commensalism to pathogenicity. Extraintestinal Pathogenic Escherichia coli (ExPEC) represent different pathovars with biphasic lifestyle – they can reside in the gut as commensals or they can escape and cause diseases elsewhere in the human body. LÄS MER

  5. 9. Studies of pore-forming bacterial protein toxins in Escherichia coli

    Författare :Constance Enow; Bernt Eric Uhlin; Sun Nyunt Wai; Mikael Rehn; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molekylärbiologi; Molecular Biology;

    Sammanfattning : Escherichia coli, a Gram-negative bacterium, which can be classified into three groups: the commensal, intestinal pathogenic (IPEC) and extra-intestinal pathogenic (ExPEC) E. coli. The cytolysin A (ClyA) protein, a 34-kDa pore-forming toxin, encoded by a gene found in both non-pathogenic and pathogenic E. LÄS MER

  7. 10. Studies of cell signalling using bacterial toxins and organic electronic devices

    Författare :Peter Kjäll; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One of the most versatile biological signalling entities is the calcium ion, Ca2+. With a characteristic spatial and temporal signalling pattern, this universal second-messenger directs diverse cellular functions, e.g. secretion of neurotransmitters at the synaptic cleft to regulation of transcription and fertilization. LÄS MER