Sökning: "autoimmune liver disease"

Visar resultat 16 - 20 av 20 avhandlingar innehållade orden autoimmune liver disease.

  1. 16. Idiopathic inflammatory myopathies and cancer : familial risk, genetics and consequences

    Författare :Weng Ian Che; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIMs) are a group of rare rheumatic inflammatory diseases (RIDs), characterised by a diverse range of clinical, serological and histopathological characteristics, with muscle weakness as a shared hallmark. While advancements in disease management have improved the survival rates of patients with IIM, the mortality rate among patients with IIM is still higher than the general population, mainly due to association with comorbidities such as cancer. LÄS MER

  3. 17. Epidemiological perspective of chronic immune thrombocytopenia

    Författare :Charlotta Ekstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis deals with different aspects of immune thrombocytopenia disease (ITP), what happens before diagnosis, characteristics of patients at treatment start and outcomes potentially related to the disease and treatment, such as thrombosis and cancer. In study one we investigate the risk of infections prior to the diagnosis of ITP. LÄS MER

  4. 18. Identification of candidate genes involved in Mercury Toxicokinetics and Mercury Induced Autoimmunity

    Författare :Hammoudi Alkaissi; Per Hultman; Said Havarinasab; Peter Söderkvist; Jesper Bo Nielsen; Johan Rönnelid; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : BACKGROUND: Autoimmune diseases require the involvement and activation of immune cells and occur when the body builds up an immune response against its own tissues. This process takes place due to the inability to distinguish self-antigen from foreign antigen. Systemic autoimmunity represents an important cause of morbidity and mortality in humans. LÄS MER

  5. 19. Genetic modification of cholera toxin B subunit for mucosal anti-infectious or anti-pathologic vaccination

    Författare :Hamid Sadeghi; Göteborgs universitet; []
    Nyckelord :Genetic fusion protein; cholera toxin B subunit; insulin; GST; Oral tolerance;

    Sammanfattning : The development of mucosal vaccines requires antigen delivery systems that can efficiently help to present vaccine antigens to the mucosal immune system. En efficient and well known antigen carrier/delivery system is the B subunit of cholera toxin (CTB). LÄS MER

  7. 20. Molecular characterization of the hepatitis C virus core protein

    Författare :Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Sammanfattning : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. LÄS MER