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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins

    Författare :Rebecca Josefson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aging; proteostasis; protein quality control; asymmetric inheritance; vesicle trafficking;

    Sammanfattning : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. LÄS MER

  3. 2. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae

    Författare :Veronica Andersson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; aging; aggregates; proteostasis; proteasome; disaggregation; peroxiredoxins; asymmetric inheritance; S. cerevisiae;

    Sammanfattning : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. LÄS MER

  4. 3. On protein oxidation, lifespan and aging in Saccharomyces cerevisiae

    Författare :Hugo Aguilaniu; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; asymmetric cell division; protein oxidation; yeast; aging; signalling pathways;

    Sammanfattning : In this thesis, we have investigated the physiology of protein oxidation and its possible role in the aging of the yeast Saccharomyces cerevisiae. There are two ways to measure yeast aging. First, they can only divide a finite number of times even when all nutrients necessary for division are provided. This is replicative aging. LÄS MER

  5. 4. On the role of actin in yeast protein quality control

    Författare :Lisa Larsson Berglund; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein quality control; Actin; Protein aggregate; Segregation; Polarisome; CCT; Huntingtin;

    Sammanfattning : Every cell is equipped with a protein quality control system to ensure the proper function of proteins. This is essential for both cell maintenance and the generation of new and healthy cells. LÄS MER

  7. 5. On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control

    Författare :David Öling; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Protein damage; Segregation; Transcriptional silencing; rDNA; UBP3; SIR2; Protein aggregates;

    Sammanfattning : Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. LÄS MER