Sökning: "Protein aggregates"

Visar resultat 1 - 5 av 210 avhandlingar innehållade orden Protein aggregates.

  1. 1. Protein Nanomaterials: : Functionalization, Self-assembly, and Applications

    Författare :Lei Wang; Niclas Solin; Olle Inganäs; German Salazar-Alvarez; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : As one of the major classes of materials that is relevant to biological function of our daily life, proteins are highly interesting in both biological and material science. Self-assembled protein amyloid nanostructures have been considered not only as aggregates in pathological tissue, but also as a kind of advanced one dimension materials in material science perspective due to their favorable characteristics including high aspect ratio, abundant surface charge groups, high stability, and tunable surface properties. LÄS MER

  2. 2. Protein complexes : assembly, structure and function

    Författare :Kristina Wilhelm; Ludmilla Ludmilla Morozova-Roche; Catharina Svanborg; Umeå universitet; []
    Nyckelord :HAMLET; ELOA; lysozyme; amyloid; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning :  Most proteins must fold into their native conformations to fulfil their biological functions. Failure of proteins to fold leads to cell pathology and a broad range of human diseases referred to as protein misfolding disease, e.g., Alzheimer’s disease, Parkinson’s disease, and type II diabetes. LÄS MER

  3. 3. On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control

    Författare :David Öling; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aging; Protein damage; Segregation; Transcriptional silencing; rDNA; UBP3; SIR2; Protein aggregates;

    Sammanfattning : Aging is characterized by a build-up of damage in organisms ranging from protists to multi-cellular species. This damage adversely affects core components such as DNA and proteins which are necessary to sustain life. LÄS MER

  4. 4. Protein-surfactant interactions

    Författare :Ank Valstar; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Physics; Fysik; Physics; Fysik; Physical Chemistry; fysikalisk kemi;

    Sammanfattning : Protein-surfactant interactions in aqueous media have been investigated. The globular proteins lysozyme and bovine serum albumin (BSA) served as model proteins. Several ionic and non-ionic surfactants were used.Fluorescence probe measurements showed that at low sodium dodecyl sulfate (SDS) concentration (< 0. LÄS MER

  5. 5. Fluorescent Probes and Protein Misfolding: Methods and Applications

    Författare :Irem Nasir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

    Sammanfattning : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. LÄS MER